Abiraterone

small molecule

Identifier: CI-DRUG-00000036
Entity page: /drug/abiraterone ↗
Edges: 177

Neighbours: 15 cancers5 genes1 variants10 trials5 approvals
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Abiraterone approved for …APPROVED_FOR8 of 5
→ approved for	Castration-Resistant Prostate Carcinomasubtype	supports	FDA ORIG	Castration-Resistant Prostate Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Castration-Resistant Prostate Carcinomasubtype 2 source records aggregated

Abiraterone predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	AR AR-V7splice 4 source records aggregated	resistance	B	Malignant Prostate Neoplasm	4	Curated	civic	graph →

Abiraterone predicts response to …PREDICTS_RESPONSE_TO1 of 1

← predicts response to

AR AR-V7splice

4 source records aggregated

resistance

Malignant Prostate Neoplasm

Curated

Abiraterone targets …TARGETS5 of 5
→ targets	SRD5A3	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	SRD5A1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	SRD5A2	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	AR	—	ANTAGONIST	—	1	Curated	chembl	graph →
→ targets	CYP17A1	—	INHIBITOR	—	1	Curated	chembl	graph →

Abiraterone investigated for …INVESTIGATED_FOR3 of 3
→ investigated for	Malignant Prostate Neoplasmcancer 4 source records aggregated	supports	B	Malignant Prostate Neoplasm	4	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Prostate Neoplasmsubtype	unknown	3	Prostate Neoplasm	1	Curated	chembl	graph →

Abiraterone investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 52show all (up to 200)
→ investigated in trials for	Malignant Prostate Neoplasmcancer 54 trials (20 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	54	Observed	clinicaltrials	graph →
→ investigated in trials for	Castration-Resistant Prostate Carcinomasubtype 29 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Castration-Resistant Prostate Carcinoma	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Prostate Neoplasmsubtype 14 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Prostate Neoplasm	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Prostate Adenocarcinoma 6 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Prostate Adenocarcinoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Castration-Sensitive Prostate Carcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Anal Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Anal Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Atypical Chronic Myeloid Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →

Abiraterone studied in …STUDIED_INderived10 of 111show all (up to 200)
→ studied in	NCT07190300Phase 1/Phase 2 · recruiting TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC) · 111 trials list this drug (47 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT07226986Phase 1/Phase 2 · recruiting A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC · 111 trials list this drug (47 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03431350Phase 2 · active not recruiting A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer · 111 trials list this drug (47 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04497844Phase 3 · active not recruiting A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC) · 111 trials list this drug (47 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04577833Phase 1 · active not recruiting A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer · 111 trials list this drug (47 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07570979Phase 1 · recruiting A Study to Investigate the Safety and Tolerability of Oral INR731 Single Agent or in Combination With Androgen Receptor Pathway Inhibitor (ARPI) in Patients With Metastatic Prostate Cancer · 111 trials list this drug (47 active)	—	—	Castration-Resistant Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06991556Phase 2 · active not recruiting An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC) · 111 trials list this drug (47 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT06863272Phase 1/Phase 2 · recruiting A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02) · 111 trials list this drug (47 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05751941Phase 2 · active not recruiting Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer · 111 trials list this drug (47 active)	—	—	Malignant Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06764485Phase 3 · active not recruiting A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer · 111 trials list this drug (47 active)	—	—	Castration-Resistant Prostate Carcinoma	1	Observed	clinicaltrials	graph →

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