Peripheral T-Cell Lymphoma, Not Otherwise Specified

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Pralatrexatesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Belinostatsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Vincristinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Vinblastinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Prednisonesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Mitoxantronesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Ifosfamidesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Gemcitabinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Etoposidesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Epirubicinsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Doxorubicinsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Decitabinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Dacarbazinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Cyclophosphamidesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Cladribinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Cisplatinsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Bleomycin

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Azacitidinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Alisertibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Alemtuzumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Vinorelbinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Vindesinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Tipifarnibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Thiotepasmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Sintilimabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Selinexorsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Prednisolonesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Pembrolizumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Pegfilgrastimother

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Oxaliplatinsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Olaparibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Nivolumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Mogamulizumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Methotrexatesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Melphalansmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Leucovorinsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Lenalidomidesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Fludarabinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Filgrastimother

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Duvelisibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Dexamethasonesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Cytarabinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Carmustinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Brentuximab Vedotinadc

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Bortezomibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Bendamustinesmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Vorinostatsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Volasertibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Tislelizumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Dasatinibsmall_molecule

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Carfilzomibother

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← investigated for

Camrelizumabmonoclonal_antibody

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Peripheral T-Cell Lymphoma, Not Otherwise Specified altered in cohorts of …ALTERED_INderived5 of 5
← altered in cohorts of	PRSS1 42 / 58 cases (72 %) · ssm · RC-PTCL	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	gdc	graph →
← altered in cohorts of	PRSS2 41 / 58 cases (71 %) · ssm · RC-PTCL	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	gdc	graph →
← altered in cohorts of	MTRNR2L6 38 / 58 cases (66 %) · ssm · RC-PTCL	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	gdc	graph →
← altered in cohorts of	OR11H12 20 / 58 cases (34 %) · ssm · RC-PTCL	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	gdc	graph →
← altered in cohorts of	POTEM 20 / 58 cases (34 %) · ssm · RC-PTCL	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	gdc	graph →

Peripheral T-Cell Lymphoma, Not Otherwise Specified altered in cohorts of …ALTERED_INderived5 of 5

← altered in cohorts of

PRSS1

42 / 58 cases (72 %) · ssm · RC-PTCL

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← altered in cohorts of

PRSS2

41 / 58 cases (71 %) · ssm · RC-PTCL

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← altered in cohorts of

MTRNR2L6

38 / 58 cases (66 %) · ssm · RC-PTCL

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← altered in cohorts of

OR11H12

20 / 58 cases (34 %) · ssm · RC-PTCL

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

← altered in cohorts of

POTEM

20 / 58 cases (34 %) · ssm · RC-PTCL

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Peripheral T-Cell Lymphoma, Not Otherwise Specified investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 81show all (up to 200)
→ investigated in trials for	Cyclophosphamidesmall_molecule 36 trials (13 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	36	Observed	clinicaltrials	graph →
→ investigated in trials for	Prednisonesmall_molecule 22 trials (11 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	22	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 20 trials (4 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall_molecule 18 trials (8 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall_molecule 17 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall_molecule 17 trials (7 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Pralatrexatesmall_molecule 13 trials (4 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall_molecule 12 trials (3 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Brentuximab Vedotinadc 11 trials (3 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall_molecule 11 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Romidepsinother 11 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Alemtuzumabmonoclonal_antibody 8 trials (0 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall_molecule 8 trials (5 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Dexamethasonesmall_molecule 8 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Belinostatsmall_molecule 7 trials (3 active) · roll-up of the cancer and its descendants	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	7	Observed	clinicaltrials	graph →

Peripheral T-Cell Lymphoma, Not Otherwise Specified investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 81show all (up to 200)

→ investigated in trials for

Cyclophosphamidesmall_molecule

36 trials (13 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Prednisonesmall_molecule

22 trials (11 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Etoposidesmall_molecule

20 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Doxorubicinsmall_molecule

18 trials (8 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Fludarabinesmall_molecule

17 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Vincristinesmall_molecule

17 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Pralatrexatesmall_molecule

13 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Lenalidomidesmall_molecule

12 trials (3 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Brentuximab Vedotinadc

11 trials (3 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Gemcitabinesmall_molecule

11 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Romidepsinother

11 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Alemtuzumabmonoclonal_antibody

8 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Azacitidinesmall_molecule

8 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Dexamethasonesmall_molecule

8 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated in trials for

Belinostatsmall_molecule

7 trials (3 active) · roll-up of the cancer and its descendants

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Peripheral T-Cell Lymphoma, Not Otherwise Specified studied in …STUDIED_INderived10 of 299show all (up to 200)
→ studied in	NCT06561048Phase 3 · recruiting Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT06630091Phase 2 · recruiting A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT04083495Phase 2 · recruiting CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT05949944Phase 1/Phase 2 · active not recruiting Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT06137144Phase 1/Phase 2 · recruiting AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies. · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT06724237Phase 3 · recruiting Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT03922724Phase 2 · active not recruiting Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT04803201Phase 2 · recruiting Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT07055477Phase 1 · recruiting A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →
→ studied in	NCT03113500Phase 2 · active not recruiting Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)	—	—	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →

Peripheral T-Cell Lymphoma, Not Otherwise Specified studied in …STUDIED_INderived10 of 299show all (up to 200)

→ studied in

NCT06561048Phase 3 · recruiting

Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT06630091Phase 2 · recruiting

A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT04083495Phase 2 · recruiting

CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT05949944Phase 1/Phase 2 · active not recruiting

Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT06137144Phase 1/Phase 2 · recruiting

AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies. · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT06724237Phase 3 · recruiting

Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT03922724Phase 2 · active not recruiting

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT04803201Phase 2 · recruiting

Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT07055477Phase 1 · recruiting

A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ studied in

NCT03113500Phase 2 · active not recruiting

Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma · condition mapped ONTOLOGY_EXACT · 299 trials mapped (84 active)

—

Observed