IDH2 R172

CI-VAR-00003714Explore in graph →CIViC 199

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 5 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia1
IDH2 R172	(prognostic)	Prognostic	B	Supports Better Outcome	4	accepted	EID1511 In a study of 1,540 patients with Acute Myeloid Leukemia, 18 patients had a mutation in IDH2(R172). IDH2(R172) mutations rarely showed co-mutation with NPM1 (odds ratio= 0.06; P=4x10-5), whereas IDH2… (full text at CIViC) PMID 27276561 · Papaemmanuil et al., 2016 · Open in CIViC	civic
Anaplastic Astrocytoma1
IDH2 R172	(prognostic)	Prognostic	B	Supports Better Outcome	5	accepted	EID483 In patients with anaplastic astrocytoma, those with mutations at R172 of IDH2 had better overall survival than wild-type patients. PMID 19228619 · Yan et al., 2009 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Glioblastoma1
IDH2 R172	(prognostic)	Prognostic	B	Supports Better Outcome	5	accepted	EID482 In patients with a glioblastoma, those with mutations at R172 of IDH2 had better overall survival than wild-type patients. PMID 19228619 · Yan et al., 2009 · Open in CIViC	civic

Peripheral T-Cell Lymphoma, Not Otherwise Specified2
IDH2 R172	(prognostic)	Prognostic	B	Does Not Support Better Outcome	3	accepted	EID627 In patients with angioimmunoblastic T-cell lymphoma (a subtype of peripheral T-cell lymphoma), IDH2 R172 mutations (N=16) had no impact on overall survival when compared to patients with wildtype IDH2… (full text at CIViC) PMID 26268241 · Wang et al., 2015 · Open in CIViC	civic
IDH2 R172	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID628 IDH2 R172 mutations were frequently observed in patients with the angioimmunoblastic T-cell lymphoma subtype of peripheral T-cell lymphomas but not observed in other subtypes. PMID 22215888 · Cairns et al., 2012 · Open in CIViC	civic

Unmapped disease1unmapped disease
IDH2 R172	(functional)	Functional	D	Supports Neomorphic	4	submitted	EID13229 In vivo study demonstrated that for 21 chondrosarcoma patient samples that had significant IDH variation, CpG methylation sequencing of these biopsies was able to linked IDH variant levels to hypermet… (full text at CIViC) PMID 24065766 · Lu et al., 2013 · Open in CIViC	civic