Giant Cell Tumor of Bone

subtype

Identifier: CI-CAN-00002773
Entity page: /cancer/giant-cell-tumor-of-bone ↗
Edges: 34

Neighbours: 1 genes1 variants8 drugs10 trials
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Giant Cell Tumor of Bone approved for …APPROVED_FOR1 of 1
← approved for	Denosumabmonoclonal_antibody 6 source records aggregated	supports	mesh_therapeutic_area	Giant Cell Tumor of Bone	6	Regulatory	ema	graph →
Giant Cell Tumor of Bone diagnostic of …DIAGNOSTIC_OF1 of 1

Giant Cell Tumor of Bone associated with …ASSOCIATED_WITH1 of 1
← associated with	H3-3A 3 source records aggregated	supports	B	Giant Cell Tumor of Bone	3	Curated	civic	graph →

Giant Cell Tumor of Bone associated with …ASSOCIATED_WITH1 of 1

← associated with

H3-3A

3 source records aggregated

supports

Giant Cell Tumor of Bone investigated in trials for …INVESTIGATED_IN_TRIALSderived8 of 8
→ investigated in trials for	Denosumabmonoclonal_antibody 9 trials (2 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Zoledronic Acidsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →

Giant Cell Tumor of Bone studied in …STUDIED_INderived10 of 22show all (up to 200)
→ studied in	NCT07609277recruiting TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of Bone · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT03449108Phase 2 · active not recruiting LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT03295981Phase 3 · recruiting Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT07315828Phase 4 · recruiting Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone Surgery · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT07227961recruiting PROMIS and Mobility Evaluation in Sarcoma Patients · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT04586660Phase 4 · active not recruiting Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT06647901Phase 1/Phase 2 · recruiting Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumors of Bone in Limbs: a Prospective, Single-center, Single-arm, Open Study · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT03301857Phase 4 · completed Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT05813665Phase 3 · not yet recruiting A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT05595603Phase 2 · recruiting Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage · condition mapped ONTOLOGY_EXACT · 22 trials mapped (9 active)	—	—	Giant Cell Tumor of Bone	1	Observed	clinicaltrials	graph →

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