Central Nervous System Neoplasm

Curated

← investigated for

Thiotepasmall_molecule

unknown

Curated

← investigated for

Thioguaninesmall_molecule

unknown

Curated

← investigated for

Temozolomidesmall_molecule

unknown

Curated

← investigated for

Procarbazinesmall_molecule

unknown

Curated

← investigated for

Prednisonesmall_molecule

unknown

Curated

← investigated for

Methotrexatesmall_molecule

unknown

Curated

← investigated for

Lomustinesmall_molecule

unknown

Curated

← investigated for

Ifosfamidesmall_molecule

unknown

Curated

← investigated for

Filgrastimother

unknown

Curated

← investigated for

Etoposidesmall_molecule

unknown

Curated

← investigated for

Cyclophosphamidesmall_molecule

unknown

Curated

← investigated for

Cisplatinsmall_molecule

unknown

Curated

← investigated for

Carmustinesmall_molecule

unknown

Curated

← investigated for

Carboplatinsmall_molecule

unknown

Curated

← investigated for

Vinorelbinesmall_molecule

unknown

Curated

← investigated for

Topotecansmall_molecule

unknown

Curated

← investigated for

Thalidomidesmall_molecule

unknown

Curated

← investigated for

Temsirolimussmall_molecule

unknown

Curated

← investigated for

Tamoxifensmall_molecule

unknown

Curated

← investigated for

Sorafenib Tosylatesmall_molecule

unknown

Curated

← investigated for

Sorafenibsmall_molecule

unknown

Curated

← investigated for

Pomalidomidesmall_molecule

unknown

Curated

← investigated for

Pazopanibsmall_molecule

unknown

Curated

← investigated for

Paclitaxelsmall_molecule

unknown

Curated

← investigated for

Oxaliplatinsmall_molecule

unknown

Curated

← investigated for

O6-Benzylguaninesmall_molecule

unknown

Curated

← investigated for

Nedaplatinsmall_molecule

unknown

Curated

← investigated for

Mechlorethaminesmall_molecule

unknown

Curated

← investigated for

Leucovorinsmall_molecule

unknown

Curated

← investigated for

Irinotecansmall_molecule

unknown

Curated

← investigated for

Imatinib Mesylatesmall_molecule

unknown

Curated

← investigated for

Imatinibsmall_molecule

unknown

Curated

← investigated for

Hydroxyureasmall_molecule

unknown

Curated

← investigated for

Hydroxycarbamidesmall_molecule

unknown

Curated

← investigated for

Gefitinibsmall_molecule

unknown

Curated

← investigated for

Erlotinib Hydrochloridesmall_molecule

unknown

Curated

← investigated for

Erlotinibsmall_molecule

unknown

Curated

← investigated for

Doxorubicinsmall_molecule

unknown

Curated

← investigated for

Dactinomycinother

unknown

Curated

← investigated for

Cytarabinesmall_molecule

unknown

Curated

← investigated for

Chlormethinesmall_molecule

unknown

Curated

← investigated for

Celecoxibsmall_molecule

unknown

Curated

← investigated for

Busulfansmall_molecule

unknown

Curated

← investigated for

Bortezomibsmall_molecule

unknown

Curated

← investigated for

Bleomycin

unknown

Curated

← investigated for

Bevacizumabmonoclonal_antibody

unknown

Curated

← investigated for

Aldesleukinother

unknown

Curated

← investigated for

Vinblastinesmall_molecule

unknown

Curated

← investigated for

Verteporfinsmall_molecule

unknown

Curated

← investigated for

Veliparibsmall_molecule

unknown

Curated

← investigated for

Vatalanibsmall_molecule

unknown

Curated

← investigated for

Vandetanibsmall_molecule

unknown

Curated

← investigated for

Valproic Acidsmall_molecule

unknown

Curated

← investigated for

Tipifarnibsmall_molecule

unknown

Curated

← investigated for

Sirolimussmall_molecule

unknown

Curated

← investigated for

Prexasertibsmall_molecule

unknown

Curated

← investigated for

Olaparibsmall_molecule

unknown

Curated

← investigated for

Melphalansmall_molecule

unknown

Curated

← investigated for

Lonafarnibsmall_molecule

unknown

Curated

← investigated for

Lenvatinibsmall_molecule

unknown

Curated

← investigated for

Lenalidomidesmall_molecule

unknown

Curated

← investigated for

Lapatinibsmall_molecule

unknown

Curated

← investigated for

Hydroxychloroquinesmall_molecule

unknown

Curated

← investigated for

Everolimussmall_molecule

unknown

Curated

← investigated for

Enzastaurinsmall_molecule

unknown

Curated

← investigated for

Dasatinibsmall_molecule

unknown

Curated

← investigated for

Cladribinesmall_molecule

unknown

Curated

← investigated for

Capecitabinesmall_molecule

unknown

Curated

← investigated for

Avelumabmonoclonal_antibody

unknown

Curated

← investigated for

Arsenic Trioxidesmall_molecule

unknown

Curated

Central Nervous System Neoplasm altered in cohorts of …ALTERED_INderived15 of 434show all (up to 200)
← altered in cohorts of	ATRNL1 456 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	MYOF 456 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	SEC23IP 456 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	BAG3 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	CACUL1 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	EIF3A 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	INPP5F 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	MCMBP 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	PRLHR 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	SORBS1 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	ACTA2 454 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	CTBP2 454 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	CYP26C1 454 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	DENND10 454 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
← altered in cohorts of	GFRA1 454 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →

Central Nervous System Neoplasm altered in cohorts of …ALTERED_INderived15 of 434show all (up to 200)

← altered in cohorts of

ATRNL1

456 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

MYOF

456 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

SEC23IP

456 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

BAG3

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

CACUL1

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

EIF3A

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

INPP5F

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

MCMBP

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

PRLHR

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

SORBS1

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

ACTA2

454 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

CTBP2

454 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

CYP26C1

454 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

DENND10

454 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

← altered in cohorts of

GFRA1

454 / 601 cases (76 %) · ssm · TCGA-GBM

—

Observed

Central Nervous System Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 257show all (up to 200)
→ investigated in trials for	Temozolomidesmall_molecule 398 trials (117 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	398	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal_antibody 156 trials (30 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	156	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall_molecule 65 trials (15 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	65	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall_molecule 64 trials (22 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	64	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 61 trials (28 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	61	Observed	clinicaltrials	graph →
→ investigated in trials for	Lomustinesmall_molecule 57 trials (15 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	57	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 53 trials (26 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	53	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 48 trials (11 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	48	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall_molecule 45 trials (11 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	45	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall_molecule 35 trials (7 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	35	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 34 trials (15 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	34	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall_molecule 30 trials (7 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	30	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 27 trials (4 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	27	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall_molecule 23 trials (5 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	23	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 22 trials (1 active) · roll-up of the cancer and its descendants	—	—	Central Nervous System Neoplasm	22	Observed	clinicaltrials	graph →

Central Nervous System Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 257show all (up to 200)

→ investigated in trials for

Temozolomidesmall_molecule

398 trials (117 active) · roll-up of the cancer and its descendants

—

398

Observed

→ investigated in trials for

Bevacizumabmonoclonal_antibody

156 trials (30 active) · roll-up of the cancer and its descendants

—

156

Observed

→ investigated in trials for

Carboplatinsmall_molecule

65 trials (15 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cyclophosphamidesmall_molecule

64 trials (22 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Nivolumabmonoclonal antibody

61 trials (28 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Lomustinesmall_molecule

57 trials (15 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Pembrolizumabmonoclonal antibody

53 trials (26 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Etoposidesmall_molecule

48 trials (11 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Vincristinesmall_molecule

45 trials (11 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Irinotecansmall_molecule

35 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ipilimumabmonoclonal antibody

34 trials (15 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cisplatinsmall_molecule

30 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Filgrastimother

27 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Everolimussmall_molecule

23 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Vorinostatsmall molecule

22 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

Diffuse Intrinsic Pontine Glioma

Central Nervous System Neoplasm studied in …STUDIED_INderived10 of 3,922show all (up to 200)
→ studied in	NCT01445288completed Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 3,922 trials mapped (1,263 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03994796Phase 2 · active not recruiting Genetic Testing in Guiding Treatment for Patients With Brain Metastases · condition mapped PROBABILISTIC · 3,922 trials mapped (1,263 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05303467Phase 1 · recruiting A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05432804Phase 1/Phase 2 · recruiting Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Glioblastoma, IDH-Wildtype	1	Observed	clinicaltrials	graph →
→ studied in	NCT07145112Phase 1 · recruiting Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07326566Phase 2 · recruiting Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07346157Phase 1/Phase 2 · recruiting Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07416188Phase 1/Phase 2 · recruiting Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02015117Phase 1 · active not recruiting Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases · condition mapped ONTOLOGY_EXACT · 3,922 trials mapped (1,263 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02389309Phase 1 · active not recruiting Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →

Central Nervous System Neoplasm studied in …STUDIED_INderived10 of 3,922show all (up to 200)

→ studied in

NCT01445288completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 3,922 trials mapped (1,263 active)

—

Observed

→ studied in

NCT03994796Phase 2 · active not recruiting

Genetic Testing in Guiding Treatment for Patients With Brain Metastases · condition mapped PROBABILISTIC · 3,922 trials mapped (1,263 active)

—

Brain Neoplasm

Observed

→ studied in

NCT05303467Phase 1 · recruiting

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Observed

Glioblastoma, IDH-Wildtype

→ studied in

NCT05432804Phase 1/Phase 2 · recruiting

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Observed

→ studied in

NCT07145112Phase 1 · recruiting

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Observed

→ studied in

NCT07326566Phase 2 · recruiting

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Observed

→ studied in

NCT07346157Phase 1/Phase 2 · recruiting

Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Medulloblastoma

Observed

→ studied in

NCT07416188Phase 1/Phase 2 · recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Observed

→ studied in

NCT02015117Phase 1 · active not recruiting

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases · condition mapped ONTOLOGY_EXACT · 3,922 trials mapped (1,263 active)

—

Brain Neoplasm

Observed

→ studied in

NCT02389309Phase 1 · active not recruiting

Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors · condition mapped CURATED_BROADER · 3,922 trials mapped (1,263 active)

—

Brain Neoplasm

Observed