Brain Neoplasm

← altered in cohorts of

PTCH1

51 / 491 cases (10 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

TERT

50 / 491 cases (10 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

DDX3X

43 / 491 cases (8.8 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

KMT2D

34 / 491 cases (6.9 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

CTNNB1

32 / 491 cases (6.5 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

KMT2C

29 / 491 cases (5.9 %) · ssm · mbl_dkfz_2017

—

Observed

← altered in cohorts of

SMARCA4

25 / 491 cases (5.1 %) · ssm · mbl_dkfz_2017

—

Observed

Brain Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 182show all (up to 200)
→ investigated in trials for	Temozolomidesmall_molecule 112 trials (31 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	112	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 54 trials (11 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	54	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 41 trials (16 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	41	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 39 trials (7 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	39	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 33 trials (7 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	33	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall_molecule 30 trials (7 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	30	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal_antibody 26 trials (11 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	26	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall_molecule 22 trials (5 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	22	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 21 trials (5 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 21 trials (4 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Lomustinesmall_molecule 17 trials (5 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 17 trials (1 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal_antibody 15 trials (8 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 15 trials (4 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 14 trials (5 active) · roll-up of the cancer and its descendants	—	—	Brain Neoplasm	14	Observed	clinicaltrials	graph →

Brain Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 182show all (up to 200)

→ investigated in trials for

Temozolomidesmall_molecule

112 trials (31 active) · roll-up of the cancer and its descendants

—

112

Observed

→ investigated in trials for

Bevacizumabmonoclonal antibody

54 trials (11 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cyclophosphamidesmall molecule

41 trials (16 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Carboplatinsmall molecule

39 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Etoposidesmall_molecule

33 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Vincristinesmall_molecule

30 trials (7 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Nivolumabmonoclonal_antibody

26 trials (11 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Irinotecansmall_molecule

22 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cisplatinsmall molecule

21 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Filgrastimother

21 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Lomustinesmall_molecule

17 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Vorinostatsmall molecule

17 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Pembrolizumabmonoclonal_antibody

15 trials (8 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Topotecansmall molecule

15 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ipilimumabmonoclonal antibody

14 trials (5 active) · roll-up of the cancer and its descendants

—

Observed

Brain Neoplasm studied in …STUDIED_INderived10 of 2,118show all (up to 200)
→ studied in	NCT05298995Phase 1 · recruiting GD2-CAR T Cells for Pediatric Brain Tumours · condition mapped ALIAS · 2,118 trials mapped (660 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06815432Phase 1 · recruiting GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma · condition mapped ALIAS · 2,118 trials mapped (660 active)	—	—	Brain Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07835412recruiting A Comparative Study of Patients Undergoing Surgery for Pituitary Neuroendocrine Tumors Detected by Different Ways · condition mapped CURATED_BROADER · 2,118 trials mapped (660 active)	—	—	Pituitary Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07848568Phase 1/Phase 2 · not yet recruiting Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)	—	—	Childhood Posterior Fossa Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04085887Phase 1/Phase 2 · recruiting Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures · condition mapped ALIAS · 2,118 trials mapped (660 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05685004Phase 2/Phase 3 · active not recruiting Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme (GBM) · condition mapped ALIAS · 2,118 trials mapped (660 active)	—	—	Brain Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07374692completed Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors · condition mapped ALIAS · 2,118 trials mapped (660 active)	—	—	Malignant Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07492316Phase 1 · active not recruiting RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · condition mapped CURATED_BROADER · 2,118 trials mapped (660 active)	—	—	Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07845994Phase 3 · not yet recruiting SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)	—	—	Craniopharyngioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01445288completed Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →

Brain Neoplasm studied in …STUDIED_INderived10 of 2,118show all (up to 200)

→ studied in

NCT05298995Phase 1 · recruiting

GD2-CAR T Cells for Pediatric Brain Tumours · condition mapped ALIAS · 2,118 trials mapped (660 active)

—

Observed

→ studied in

NCT06815432Phase 1 · recruiting

GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma · condition mapped ALIAS · 2,118 trials mapped (660 active)

—

Brain Glioblastoma

Observed

Pituitary Neuroendocrine Tumor

→ studied in

NCT07835412recruiting

A Comparative Study of Patients Undergoing Surgery for Pituitary Neuroendocrine Tumors Detected by Different Ways · condition mapped CURATED_BROADER · 2,118 trials mapped (660 active)

—

Observed

Childhood Posterior Fossa Ependymoma

→ studied in

NCT07848568Phase 1/Phase 2 · not yet recruiting

Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)

—

Observed

→ studied in

NCT04085887Phase 1/Phase 2 · recruiting

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures · condition mapped ALIAS · 2,118 trials mapped (660 active)

—

Observed

→ studied in

NCT05685004Phase 2/Phase 3 · active not recruiting

Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme (GBM) · condition mapped ALIAS · 2,118 trials mapped (660 active)

—

Brain Glioblastoma

Observed

→ studied in

NCT07374692completed

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors · condition mapped ALIAS · 2,118 trials mapped (660 active)

—

Malignant Brain Neoplasm

Observed

→ studied in

NCT07492316Phase 1 · active not recruiting

RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · condition mapped CURATED_BROADER · 2,118 trials mapped (660 active)

—

Observed

→ studied in

NCT07845994Phase 3 · not yet recruiting

SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)

—

Craniopharyngioma

Observed

Diffuse Intrinsic Pontine Glioma

→ studied in

NCT01445288completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 2,118 trials mapped (660 active)

—

Observed