Gene
ZNF384
zinc finger protein 384
Explore in graph →CI-GENE-00039708HGNC:11955 ENSG00000126746 NCBI 171017 Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27607436
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ZNF384 Fusion1 | ||||||||
| (diagnostic) | Acute Biphenotypic Leukemia | Diagnostic | C | Supports Positive | 1 | submitted | EID9708A case report of a 74 year old female who was diagnosed with MPAL, B/myeloid with bone marrow blasts were positive for myeloperoxidase, CD19, and CD22. Chromosome analysis showed 46,XX,+1,der(1;18)(q1… (full text at CIViC) PMID 27607436 · Yamamoto et al., 2016 · Open in CIViC | civic |
| ZNF384 Fusion3 | ||||||||
| (diagnostic) | B-lymphoblastic Leukaemia/lymphoma With Other Defined Genetic AlterationsUNRESOLVED | Diagnostic | B | Supports Positive | 4 | accepted | EID12466In this 2017 study, the authors analyzed 91 pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients and an additional 122 classified as "B-others" lacking conventional genetic abnor… | |
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Testicular Germ Cell Tumors TCGA-TGCT | Testicular Germ Cell Tumor | Ssm |
Literature
Linked publications (3)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)