Acute Biphenotypic Leukemia — Variants & evidence

Acute Biphenotypic Leukemia — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KMT2A Fusion1
EPZ004777	Predictive	D	Supports Sensitivity Response	4	submitted	EID7582 KMT2A (MLL) gene encodes a transcriptional co-activator harboring a SET domain with H3K4 histone methyl transferase activity which mediates chromatin modifications associated with epigenetic transcrip… (full text at CIViC) PMID 21741596 · Daigle et al., 2011 · Open in CIViC	civic
ZNF384 Fusion1
(diagnostic)	Diagnostic	C	Supports Positive	1	submitted	EID9708 A case report of a 74 year old female who was diagnosed with MPAL, B/myeloid with bone marrow blasts were positive for myeloperoxidase, CD19, and CD22. Chromosome analysis showed 46,XX,+1,der(1;18)(q1… (full text at CIViC) PMID 27607436 · Yamamoto et al., 2016 · Open in CIViC	civic

Data updated 21 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.