Gene

UGT1A1

UDP glucuronosyltransferase family 1 member A1

Explore in graph →CI-GENE-00037936HGNC:12530 ENSG00000241635 NCBI 54658 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
UGT1A1 UGT1A1*281
Belinostat	Malignant NeoplasmALIAS	Predictive	A	Supports Adverse Response	5	accepted	EID1792 The FDA approved package insert for Belinostat recommends dose adjustment for UGT1A1*28 allele homozygotes. PMID 26313268 · Goey et al., 2016 · Open in CIViC	civic
UGT1A1 UGT1A1*601
Belinostat	Malignant NeoplasmALIAS	Predictive	B	Supports Adverse Response	4	accepted	EID1795 In a phase 1 trial belinostat (400-800mg/m2/24h) was administered to 25 patients in combination with cisplatin and etoposide. Endpoints were associations between genotype of UGT1A1 and pharmacokinetic…

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Melanomas (TCGA, Cell 2015) skcm_tcga_pub_2015	Cutaneous Melanoma	Ssm	56	346	16.2%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.
· J Clin Pharmacol · 2016 · PMID 26313268 · validated civic_curation pubmed