Publication
Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Neoplasmcivic_curation1.00
- drugBelinostatcivic_curation1.00
- geneUGT1A1civic_curation1.00
- variantUGT1A1 UGT1A1*28civic_curation1.00
- variantUGT1A1 UGT1A1*60civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26313268
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| UGT1A1 UGT1A1*281 | ||||||||
| Belinostat | Malignant NeoplasmALIAS | Predictive | A | Supports Adverse Response | 5 | accepted | EID1792The FDA approved package insert for Belinostat recommends dose adjustment for UGT1A1*28 allele homozygotes. PMID 26313268 · Goey et al., 2016 · Open in CIViC | civic |
| UGT1A1 UGT1A1*601 | ||||||||
| Belinostat | Malignant NeoplasmALIAS | Predictive | B | Supports Adverse Response | 4 | accepted | EID1795In a phase 1 trial belinostat (400-800mg/m2/24h) was administered to 25 patients in combination with cisplatin and etoposide. Endpoints were associations between genotype of UGT1A1 and pharmacokinetic… (full text at CIViC) PMID 26313268 · Goey et al., 2016 · Open in CIViC | civic |