Gene

SLCO1B1

solute carrier organic anion transporter family member 1B1

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SLCO1B1 N130D1
Methotrexate	Malignant NeoplasmALIAS	Predictive	B	Supports Adverse Response	3	accepted	EID1842 499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The SLCO1B1 RS2306283 variant was significantly associated with MTX AUC0-48h and as such associated with in… (full text at CIViC) PMID 23652803 · Radtke et al., 2013 · Open in CIViC	civic
SLCO1B1 RS41490561
Methotrexate	Malignant NeoplasmALIAS	Predictive	B	Supports Adverse Response	3	accepted	EID1841 499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The SLCO1B1 rs4149056 variant was significantly associated with MTX AUC0-48h and as such associated with in…

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved3 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Testicular Germ Cell Tumors TCGA-TGCT	Testicular Germ Cell Tumor	Ssm

Literature

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.