Publication
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerMalignant Neoplasmcivic_curation1.00
- drugMethotrexatecivic_curation1.00
- geneSLCO1B1civic_curation1.00
- geneTYMScivic_curation1.00
- variantSLCO1B1 N130Dcivic_curation1.00
- variantSLCO1B1 RS4149056civic_curation1.00
- variantTYMS RS34743033civic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23652803
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SLCO1B1 N130D1 | ||||||||
| Methotrexate | Malignant NeoplasmALIAS | Predictive | B | Supports Adverse Response | 3 | accepted | EID1842499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The SLCO1B1 RS2306283 variant was significantly associated with MTX AUC0-48h and as such associated with in… (full text at CIViC) PMID 23652803 · Radtke et al., 2013 · Open in CIViC | civic |
| SLCO1B1 RS41490561 | ||||||||
| Methotrexate | Malignant NeoplasmALIAS | Predictive | B | Supports Adverse Response | 3 | accepted | EID1841499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The SLCO1B1 rs4149056 variant was significantly associated with MTX AUC0-48h and as such associated with in… (full text at CIViC) PMID 23652803 · Radtke et al., 2013 · Open in CIViC | civic |
| TYMS RS347430331 | ||||||||
| Methotrexate | Malignant NeoplasmALIAS | Predictive | B | Supports Adverse Response | 3 | accepted | EID1843499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The TYMS rs34743033 tandem repeat polymorphism was the only significant predictor of stomatitis in a multip… (full text at CIViC) PMID 23652803 · Radtke et al., 2013 · Open in CIViC | civic |