Gene

SEPTIN14

septin 14

Explore in graph →CI-GENE-00030286HGNC:33280 ENSG00000154997 NCBI 346288 Cancer geneApproved

Curated evidence

Clinical evidence (13)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–13 of 13 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EGFR Amplification + EGFR EGFRVIII + SEPTIN14 FusionSEPTIN14 EGFR1
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	3	submitted	EID11154 RNASeq data from 161 primary GBM samples and 24 glioma spheroids were analysed for gene fusion events. EGFR::SEPT14 was found to be the most common fusion event, after the well-documented FGFR3::TACC3… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
EGFR Amplification + SEPTIN14 FusionSEPTIN14 EGFR3
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic

Cohorts

Alteration frequency by cohort (0)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A Rare EGFR-SEPT14 Fusion in a Patient with Colorectal Adenocarcinoma Responding to Erlotinib.
· Oncologist · 2020 · PMID 32162810 · validated civic_curation pubmed

SEPTIN14 Fusion8
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	2	submitted	EID11153 The study presents a new fusion detection algorithm, CICERO ("CICERO Is Clipping Extended for RNA Optimization"). The authors compare their pipeline to gene fusions reported by TCGA network, using the… (full text at CIViC) PMID 32466770 · Tian et al., 2020 · Open in CIViC	civic
〃	GlioblastomaCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	2	submitted	EID12363 In this article, the authors develop a method to detect gene fusion events using RNA-seq data and apply it to nearly 7,000 samples from The Cancer Genome Atlas (TCGA). Through this approach, they iden… (full text at CIViC) PMID 25204415 · Stransky et al., 2014 · Open in CIViC	civic
〃	Lung Adenocarcinoma	Oncogenic	C	Supports Oncogenicity	2	submitted	EID11005 A case report of a 56 year old male with metastatic lung adenocarcinoma to the leptomeninges, in whom two rare EGFR::SEPT14 fusions were identified. On second recurrence, NGS was performed on the CSF,… (full text at CIViC) PMID 34486539 · Zheng et al., 2022 · Open in CIViC	civic
〃	IDH-wildtype GlioblastomaUNRESOLVED	Oncogenic	C	Supports Oncogenicity	1	submitted	EID11004 170 cases of IDH-wildtype GBM were screened using whole genome SNP arrays for chromothripsis. 66 cases of 170 demonstrated chromothripsis, of which 52 had adequate RNA available for RNA sequencing. Fr… (full text at CIViC) PMID 33074125 · Ah-Pine et al., 2021 · Open in CIViC	civic
〃	GlioblastomaCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	4	submitted	EID10843 Analysing whole transcriptome data from 185 GBM samples from TCGA, EGFR fusion events were found in 7.6% (14) of the cohort. In 6 of 14 cases, in-frame EGFR::SEPT14 (e24:e10) fusions were detected (3.… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
Erlotinib + LapatinibSequential	GlioblastomaCURATED_BROADER	Predictive	D	Supports Sensitivity Response	3	submitted	EID11002 Analysing whole transcriptome data from 185 GBM samples from TCGA, EGFR fusion events were found in 7.6% (14) of the cohort. In 6 of 14 cases, in-frame EGFR::SEPT14 (e24:e10) fusions were detected (3.… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
〃	GlioblastomaCURATED_BROADER	Predictive	D	Supports Sensitivity Response	2	submitted	EID11155 The primary aim of the study was the characterisation of fusion events in 185 GBM samples. As part of this study, a GBM xenograft with EGFR::SEPT14 fusion, derived from a heavily pre-treated patient, … (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
Carboplatin + Icotinib + Paclitaxel LiposomeSequential	Lung Adenocarcinoma	Predictive	C	Supports Sensitivity Response	2	submitted	EID10914 Case report of a 62-year-old woman with lung adenocarcinoma. She underwent treatment with liposome-paclitaxel and carboplatin. They detected EGFR-SEPT14 fusion (N-terminal amino acids of EGFR and C-te… (full text at CIViC) PMID 31345345 · Zhu et al., 2019 · Open in CIViC	civic