SEPTIN14 Fusion

Loading variant…

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Colon Adenocarcinoma1
EGFR Amplification AND EGFR::SEPTIN14 Fusion	Erlotinib	Predictive	C	Supports Sensitivity Response	2	accepted	EID10913 Case report describing a 63-year-old patient with colorectal adenocarcinoma. He started treatment with XELOX and bevacizumab. After findings of disease progression, they changed to bevacizumab and FOL… (full text at CIViC) PMID 32162810 · Li et al., 2020 · Open in CIViC	civic
Gastric Adenocarcinoma1
EGFR Amplification AND EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	submitted	EID11003 A case report of a 49 year old female with gastric signet ring cell carcinoma, in whom a genomic screen of cf tumour DNA revealed an EGFR::SEPT14 fusion at a VAF of 45.3%. The fusion was confirmed by … (full text at CIViC) PMID ·

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

Colon Adenocarcinoma1

EGFR Amplification AND EGFR::SEPTIN14 Fusion

Erlotinib

Predictive

Supports Sensitivity Response

accepted

EID10913

Case report describing a 63-year-old patient with colorectal adenocarcinoma. He started treatment with XELOX and bevacizumab. After findings of disease progression, they changed to bevacizumab and FOL… (full text at CIViC)

PMID 32162810 · Li et al., 2020 · Open in CIViC

civic

Gastric Adenocarcinoma1

EGFR Amplification AND EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11003

A case report of a 49 year old female with gastric signet ring cell carcinoma, in whom a genomic screen of cf tumour DNA revealed an EGFR::SEPT14 fusion at a VAF of 45.3%. The fusion was confirmed by … (full text at CIViC)

PMID ·

Glioblastoma8
EGFR Amplification AND EGFR EGFRVIII AND EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	3	submitted	EID11154 RNASeq data from 161 primary GBM samples and 24 glioma spheroids were analysed for gene fusion events. EGFR::SEPT14 was found to be the most common fusion event, after the well-documented FGFR3::TACC3… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
EGFR Amplification AND EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	2	submitted	EID11151 Seminal paper presenting the original analysis of the TCGA Glioblastoma dataset, of over 500 glioblastoma genomes. EFGR::SEPT14 fusion was found in 6 cases by WGS and confirmed by RNASeq. The fusion i… (full text at CIViC) PMID 24120142 · Brennan et al., 2013 · Open in CIViC	civic
EGFR EGFRVIII AND EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	2	submitted	EID11152 The study utilises a targeted gene fusion RNASeq panel to screen 356 diffuse gliomas for fusion events. Of these, 155 cases were IDH-wildtype glioblastomas, of which 2 harboured an EGFR::SEPT14 fusion… (full text at CIViC) PMID 32761533 · Woo et al., 2020 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	2	submitted	EID11153 The study presents a new fusion detection algorithm, CICERO ("CICERO Is Clipping Extended for RNA Optimization"). The authors compare their pipeline to gene fusions reported by TCGA network, using the… (full text at CIViC) PMID 32466770 · Tian et al., 2020 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	4	submitted	EID10843 Analysing whole transcriptome data from 185 GBM samples from TCGA, EGFR fusion events were found in 7.6% (14) of the cohort. In 6 of 14 cases, in-frame EGFR::SEPT14 (e24:e10) fusions were detected (3.… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	Erlotinib + LapatinibSequential	Predictive	D	Supports Sensitivity Response	3	submitted	EID11002 Analysing whole transcriptome data from 185 GBM samples from TCGA, EGFR fusion events were found in 7.6% (14) of the cohort. In 6 of 14 cases, in-frame EGFR::SEPT14 (e24:e10) fusions were detected (3.… (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	Erlotinib + LapatinibSubstitutes	Predictive	D	Supports Sensitivity Response	2	submitted	EID11155 The primary aim of the study was the characterisation of fusion events in 185 GBM samples. As part of this study, a GBM xenograft with EGFR::SEPT14 fusion, derived from a heavily pre-treated patient, … (full text at CIViC) PMID 23917401 · Frattini et al., 2013 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	2	submitted	EID12363 In this article, the authors develop a method to detect gene fusion events using RNA-seq data and apply it to nearly 7,000 samples from The Cancer Genome Atlas (TCGA). Through this approach, they iden… (full text at CIViC) PMID 25204415 · Stransky et al., 2014 · Open in CIViC	civic

Glioblastoma8

EGFR Amplification AND EGFR EGFRVIII AND EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11154

RNASeq data from 161 primary GBM samples and 24 glioma spheroids were analysed for gene fusion events. EGFR::SEPT14 was found to be the most common fusion event, after the well-documented FGFR3::TACC3… (full text at CIViC)

PMID 23917401 · Frattini et al., 2013 · Open in CIViC

civic

EGFR Amplification AND EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11151

Seminal paper presenting the original analysis of the TCGA Glioblastoma dataset, of over 500 glioblastoma genomes. EFGR::SEPT14 fusion was found in 6 cases by WGS and confirmed by RNASeq. The fusion i… (full text at CIViC)

PMID 24120142 · Brennan et al., 2013 · Open in CIViC

civic

EGFR EGFRVIII AND EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11152

The study utilises a targeted gene fusion RNASeq panel to screen 356 diffuse gliomas for fusion events. Of these, 155 cases were IDH-wildtype glioblastomas, of which 2 harboured an EGFR::SEPT14 fusion… (full text at CIViC)

PMID 32761533 · Woo et al., 2020 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11153

The study presents a new fusion detection algorithm, CICERO ("CICERO Is Clipping Extended for RNA Optimization"). The authors compare their pipeline to gene fusions reported by TCGA network, using the… (full text at CIViC)

PMID 32466770 · Tian et al., 2020 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID10843

Analysing whole transcriptome data from 185 GBM samples from TCGA, EGFR fusion events were found in 7.6% (14) of the cohort. In 6 of 14 cases, in-frame EGFR::SEPT14 (e24:e10) fusions were detected (3.… (full text at CIViC)

PMID 23917401 · Frattini et al., 2013 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

Erlotinib + LapatinibSequential

Predictive

Supports Sensitivity Response

submitted

EID11002

PMID 23917401 · Frattini et al., 2013 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

Erlotinib + LapatinibSubstitutes

Predictive

Supports Sensitivity Response

submitted

EID11155

The primary aim of the study was the characterisation of fusion events in 185 GBM samples. As part of this study, a GBM xenograft with EGFR::SEPT14 fusion, derived from a heavily pre-treated patient, … (full text at CIViC)

PMID 23917401 · Frattini et al., 2013 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID12363

In this article, the authors develop a method to detect gene fusion events using RNA-seq data and apply it to nearly 7,000 samples from The Cancer Genome Atlas (TCGA). Through this approach, they iden… (full text at CIViC)

PMID 25204415 · Stransky et al., 2014 · Open in CIViC

civic

Lung Adenocarcinoma2
EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	submitted	EID11005 A case report of a 56 year old male with metastatic lung adenocarcinoma to the leptomeninges, in whom two rare EGFR::SEPT14 fusions were identified. On second recurrence, NGS was performed on the CSF,… (full text at CIViC) PMID 34486539 · Zheng et al., 2022 · Open in CIViC	civic
EGFR::SEPTIN14 Fusion	Carboplatin + Icotinib + Paclitaxel LiposomeSequential	Predictive	C	Supports Sensitivity Response	2	submitted	EID10914 Case report of a 62-year-old woman with lung adenocarcinoma. She underwent treatment with liposome-paclitaxel and carboplatin. They detected EGFR-SEPT14 fusion (N-terminal amino acids of EGFR and C-te… (full text at CIViC) PMID 31345345 · Zhu et al., 2019 · Open in CIViC	civic

Lung Adenocarcinoma2

EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11005

A case report of a 56 year old male with metastatic lung adenocarcinoma to the leptomeninges, in whom two rare EGFR::SEPT14 fusions were identified. On second recurrence, NGS was performed on the CSF,… (full text at CIViC)

PMID 34486539 · Zheng et al., 2022 · Open in CIViC

civic

EGFR::SEPTIN14 Fusion

Carboplatin + Icotinib + Paclitaxel LiposomeSequential

Predictive

Supports Sensitivity Response

submitted

EID10914

Case report of a 62-year-old woman with lung adenocarcinoma. She underwent treatment with liposome-paclitaxel and carboplatin. They detected EGFR-SEPT14 fusion (N-terminal amino acids of EGFR and C-te… (full text at CIViC)

PMID 31345345 · Zhu et al., 2019 · Open in CIViC

civic

IDH-wildtype Glioblastoma1unmapped disease
EGFR::SEPTIN14 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID11004 170 cases of IDH-wildtype GBM were screened using whole genome SNP arrays for chromothripsis. 66 cases of 170 demonstrated chromothripsis, of which 52 had adequate RNA available for RNA sequencing. Fr… (full text at CIViC) PMID 33074125 · Ah-Pine et al., 2021 · Open in CIViC	civic

IDH-wildtype Glioblastoma1unmapped disease

EGFR::SEPTIN14 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11004

170 cases of IDH-wildtype GBM were screened using whole genome SNP arrays for chromothripsis. 66 cases of 170 demonstrated chromothripsis, of which 52 had adequate RNA available for RNA sequencing. Fr… (full text at CIViC)

PMID 33074125 · Ah-Pine et al., 2021 · Open in CIViC

civic

Evidence by cancer (13 items)

Clinical significance (0)