Gene

ROBO4

roundabout guidance receptor 4

Explore in graph →CI-GENE-00027318HGNC:17985 ENSG00000154133 NCBI 54538 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ROBO4 EXPRESSION1
Angiogenesis Inhibitor	Malignant NeoplasmALIAS	Predictive	B	Does Not Support Sensitivity Response	1	accepted	EID1166 Biomarkers for Response to antiangiogenic treatment were screened for in hepatocellular cancer (n = 11), renal cell cancer (n = 7) and non-small cell lung cancer (n = 2). Increased expression of tumor… (full text at CIViC) PMID 26956051 · Pircher et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Small Cell Lung Cancer (Johns Hopkins, Nat Genet 2012) sclc_jhu	Lung Small Cell Carcinoma	Ssm	5	80

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies.
· Oncotarget · 2016 · PMID 26956051 · validated civic_curation pubmed