PATZ1 Fusion

CI-VAR-00001504Explore in graph →CIViC 5373

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Round Cell Sarcoma with EWSR1-non-ETS Fusion4
EWSR1::PATZ1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12735 This case series study reported 11 neoplasms harboring the EWSR1::PATZ1 gene fusion with 7 in the soft tissue and 4 in the brain. Paired-end sequencing identified a somatic intra-chromosomal paracentr… (full text at CIViC) PMID 31189996 · Bridge et al., 2019 · Open in CIViC	civic
EWSR1::PATZ1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12738 This case series study presented clinical, histopathological, and molecular findings of 9 EWSR1::PATZ1-rearranged sarcomas, including one previously reported case. The cohort included 4 males and 5 fe… (full text at CIViC) PMID 33012788 · Michal et al., 2021 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.