Round Cell Sarcoma with EWSR1-non-ETS Fusion

This analysis of small round cell tumors of the bone identified 3 with EWSR1::NFATC2 fusions and 1 with a FUS::NFATC2 fusion. The authors extended their review to an additional 45 cases in the litera… (full text at CIViC)

PMID 31078563 · Diaz-Perez et al., 2019 · Open in CIViC

A small case series examined molecular features along with clinicopathologic and immunohistochemical characteristics of sarcomas with EWSR1::NFATC2 gene fusions. The study included 6 cases (5 males an… (full text at CIViC)

PMID 30994538 · Wang et al., 2019 · Open in CIViC

This landmark study represents the first description of the EWSR1::NFATC2 fusion in Ewing-like sarcomas, leading to the establishment of 'round cell sarcoma with EWSR1-non-ETS fusions' as a new diseas… (full text at CIViC)

PMID 19318479 · Szuhai et al., 2009 · Open in CIViC

This case series study reported 11 neoplasms harboring the EWSR1::PATZ1 gene fusion with 7 in the soft tissue and 4 in the brain. Paired-end sequencing identified a somatic intra-chromosomal paracentr… (full text at CIViC)

PMID 31189996 · Bridge et al., 2019 · Open in CIViC

This case series study presented clinical, histopathological, and molecular findings of 9 EWSR1::PATZ1-rearranged sarcomas, including one previously reported case. The cohort included 4 males and 5 fe… (full text at CIViC)

PMID 33012788 · Michal et al., 2021 · Open in CIViC

This case series study presented clinical, histopathological, and molecular findings of 9 EWSR1-PATZ1-rearranged sarcomas, including one previously reported case (case 3). The cohort included 4 males …

This analysis of small round cell tumors of the bone identified 3 with EWSR1::NFATC2 fusions and 1 with a FUS::NFATC2 fusion. The authors extended their review to an additional 45 cases in the litera… (full text at CIViC)

PMID 31078563 · Diaz-Perez et al., 2019 · Open in CIViC

This is the first study to identify the FUS::NFATC2 gene fusion. Using multi-omics approach and targeted sequencing, the authors comprehensively characterized the molecular landscape of a large cohort… (full text at CIViC)

PMID 25010205 · Brohl et al., 2014 · Open in CIViC

This case series presented 7 NFATC2-rearranged sarcomas, including 4 EWSR1::NFATC2 and 3 FUS::NFATC2 cases, and developed an ACAN-encoding aggrecan immunohistochemistry as a diagnostic tool for these …