Gene

MN1

MN1 proto-oncogene, transcriptional regulator

Explore in graph →CI-GENE-00014731HGNC:7180 ENSG00000169184 NCBI 4330 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MN1 Rearrangement3
(diagnostic)	Astroblastoma, MN1-Altered	Diagnostic	B	Supports Positive	4	accepted	EID12078 10 of 27 cases of histologically defined astroblastomas studied demonstrated an inferred MN1 rearrangement by break-apart FISH testing. Of these, all eight cases with material available for methylati… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic
(prognostic)	Astroblastoma, MN1-Altered	Prognostic	B	Supports Better Outcome	4	accepted	EID12079 In an analysis of 27 histologically defined astroblastomas, 10 had MN1 rearrangements, 7 had BRAF p.V600E mutations, 2 had RELA rearrangements, and 8 had none of these drivers identified. Astroblasto… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC

Cohorts

Alteration frequency by cohort (14)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved14 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Adenocarcinoma Organoids (MSK, Cell 2014) prad_mskcc_cheny1_organoids_2014	Prostate Adenocarcinoma	Ssm	2

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis.
· Acta Neuropathol Commun · 2019 · PMID 30876455 · validated civic_curation pubmed
MN1 rearrangement in astroblastoma: study of eight cases and review of literature.
· Brain Tumor Pathol · 2019 · PMID 31111274 · validated civic_curation pubmed