MN1 Rearrangement

CI-VAR-00003966Explore in graph →CIViC 4993

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Astroblastoma, MN1-Altered3
MN1 Rearrangement	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12077 The authors reviewed histologically diagnosed astroblastomas at the National Institute of Mental Health and Neurosciences (Bangalore, India) between 2011 and 2018. Eight cases were identified and were… (full text at CIViC) PMID 31111274 · Mhatre et al., 2019 · Open in CIViC	civic
MN1 Rearrangement	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12078 10 of 27 cases of histologically defined astroblastomas studied demonstrated an inferred MN1 rearrangement by break-apart FISH testing. Of these, all eight cases with material available for methylati… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.