Astroblastoma, MN1-Altered — Variants & evidence

Astroblastoma, MN1-Altered — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BEND2 Fusion1
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID8510 The authors studied tumors carrying a diagnosis of CNS primitive neuroectodermal tumors (PNETs). They identified four novel DNA methylation-defined brain tumor groups. One group, designated high-grade… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC	civic
BEND2 Fusion + CXXC5 FusionCXXC5 BEND21
(diagnostic)	Diagnostic	B	Supports Positive	3	submitted	EID12688 In a clinicopathologic and molecular series of astroblastoma (n = 8; biomarker MN1 rearrangement; primary endpoint diagnostic detection), MN1 break-apart FISH identified rearrangements in all informat… (full text at CIViC) PMID 28990708 · Hirose et al., 2018 · Open in CIViC	civic
MN1 Rearrangement3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12078 10 of 27 cases of histologically defined astroblastomas studied demonstrated an inferred MN1 rearrangement by break-apart FISH testing. Of these, all eight cases with material available for methylati… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic
(prognostic)	Prognostic	B	Supports Better Outcome	4	accepted	EID12079 In an analysis of 27 histologically defined astroblastomas, 10 had MN1 rearrangements, 7 had BRAF p.V600E mutations, 2 had RELA rearrangements, and 8 had none of these drivers identified. Astroblasto… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic
(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12077 The authors reviewed histologically diagnosed astroblastomas at the National Institute of Mental Health and Neurosciences (Bangalore, India) between 2011 and 2018. Eight cases were identified and were…

Data updated 9 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.