Sarcoma with BCOR Genetic Alterations — Variants & evidence

Sarcoma with BCOR Genetic Alterations — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CCNB3 Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9011 This study consists of a cohort of 42 pediatric and adult patients with sarcomas that were classified as undifferentiated. Six of the forty two patients had BCOR::CCNB3 fusions detected by whole trans… (full text at CIViC) PMID 25360585 · Peters et al., 2015 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID10111 Kao, et al. (2018) presented 36 BCOR::CCNB3 sarcoma cases (86% were males; mean and median age at presentation was 15 years (range from 2 to 44 years); 78% showed mainly primitive round cells morpholo… (full text at CIViC) PMID 29300189 · Kao et al., 2018 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID12568 In this 2017 study reviewing 753 sarcoma cases, 11 tumors with the BCOR::CCNB3 fusion were identified using immunohistochemistry and RT-PCR. These tumors were found exclusively in males, with a mean a… (full text at CIViC) PMID 28420319 · Ludwig et al., 2017 · Open in CIViC	civic
CCNB3 Fusion + MAML3 FusionCCNB3 MAML31
(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11590 BCOR expression was evaluated in a cohort of 25 small blue round cell tumors (SBRCTs) with BCOR fusions (BCOR::MAML3, BCOR::CCNB3), BCOR exon 15 ITDs, or YWHAE-NUTM2B fusion (which is known to upregul… (full text at CIViC) PMID 27428733 · Kao et al., 2016 · Open in CIViC	civic

Data updated 10 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.