KLF5 E419K

CI-VAR-00000736Explore in graph →CIViC 4306

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
KLF5 E419K	(functional)	Functional	D	Supports Neomorphic	2	accepted	EID11030 Wild-type and mutant (D418N, E419K, E419Q) KLF5 were infected into HEK293T cells and DNA binding specificity evaluated by ChIP-Seq. The binding motif for wild-type KLF5 has a C or T at the 5th nucleot… (full text at CIViC) PMID 28963353 · Zhang et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.