Publication

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

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Cancer Discov2018PMID 28963353PMC5760289stubpubmedPublished

Abstract

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Linked entities

Linked entities (3)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 3

geneKLF5civic_curation1.00
variantKLF5 E419Kcivic_curation1.00
variantKLF5 E419Qcivic_curation1.00

Curated evidence

Evidence citing this paper (2)

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KLF5 E419K1
(functional)	—UNRESOLVED	Functional	D	Supports Neomorphic	2	accepted	EID11030 Wild-type and mutant (D418N, E419K, E419Q) KLF5 were infected into HEK293T cells and DNA binding specificity evaluated by ChIP-Seq. The binding motif for wild-type KLF5 has a C or T at the 5th nucleot… (full text at CIViC) PMID 28963353 · Zhang et al., 2018 · Open in CIViC	civic
KLF5 E419Q1
(functional)	—UNRESOLVED	Functional	D	Supports Neomorphic	2	accepted	EID11031 Wild-type and mutant (D418N, E419K, E419Q) KLF5 were infected into HEK293T cells and DNA binding specificity evaluated by ChIP-Seq. The binding motif for wild-type KLF5 has a C or T at the 5th nucleot… (full text at CIViC) PMID 28963353 · Zhang et al., 2018 · Open in CIViC	civic