KLF4 K409Q

CI-VAR-00002124Explore in graph →CIViC 3440

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
KLF4 K409Q	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID9557 Transcriptomic analysis was performed on 17 meningiomas, 7 with K409Q mutation and 10 wild-type for KLF4. KLF4 K409Q tumors showed altered expression profiles with upregulation of the hypoxia and glyc… (full text at CIViC) PMID 32245394 · von Spreckelsen et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.