Gene
KEAP1
kelch like ECH associated protein 1
Explore in graph →CI-GENE-00006823HGNC:23177 ENSG00000079999 NCBI 9817 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (6)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 39385035
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KEAP1 Mutation3 | ||||||||
| Chemotherapy + Durvalumab Regimen + TremelimumabCombination | Lung Non-Small Cell CarcinomaCURATED_BROADER | Predictive | A | Supports Sensitivity Response | 5 | submitted | EID12419The POSEIDON (NCT03164616) open-label, randomized phase 3 trial included 1,013 patients with metastatic non-small-cell lung cancer (NSCLC), of whom 637 had nonsquamous histology and 612 were evaluable… (full text at CIViC) PMID 39385035 · Skoulidis et al., 2024 · Open in CIViC | civic |
| Cisplatin/Pembrolizumab/Pemetrexed Regimen | Lung Non-Small Cell CarcinomaCURATED_BROADER | Predictive | B | Supports Resistance | 4 | submitted | ||
Cohorts
Alteration frequency by cohort (116)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 31871300
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Tumors with TRK fusions (MSK, Clin Cancer Res 2020) ntrk_msk_2019 | unmapped | Ssm | 1 | 106 |
Literature
Linked publications (2)
25 per page, newest first.
pubmedProvenance
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)