KEAP1 G417W

CI-VAR-00001734Explore in graph →CIViC 5449

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
STK11 Rearrangement exon 1 AND KEAP1 G417W	Chemoimmunotherapy + Palliative Radiation TherapySequential	Predictive	C	Supports Resistance	2	submitted	EID12933 In a case report of KRAS wild‑type NSCLC (n = 1, age 53 male) a tumor harbored concurrent STK11 (rearrangement exon 1) and KEAP1 (G417W) mutations, along with additional somatic alterations (including… (full text at CIViC) PMID 36858519 · Sumii et al., 2023 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.