IGF2

insulin like growth factor 2

Explore in graph →CI-GENE-00005490HGNC:5466 ENSG00000167244 NCBI 3481 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IGF2 Overexpression5
Cabazitaxel + LinsitinibCombination	Malignant Prostate Neoplasm	Predictive	D	Supports Sensitivity Response	3

Cohorts

Alteration frequency by cohort (28)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved28 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024	Endometrial Carcinoma	Ssm	5	69

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.
· Cancer Cell · 2015 · PMID 25670080 · validated civic_curation pubmed