HOXB13 — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HOXB13 G84E2
(predisposing)	Malignant Prostate Neoplasm	Predisposing	B	Supports Predisposition	4	accepted	EID1760 G84E (rs138213197) substitution in HOXB13 is associated with an increased risk for prostate cancer. 49 out of 9012 male patients in the Mayo Clinic Biobank were carriers. 31% of patients were diagnose… (full text at CIViC) PMID 26108461 · Beebe-Dimmer et al., 2015 · Open in CIViC	civic
〃	Malignant Prostate Neoplasm	Predisposing	B	Supports Predisposition	4	accepted	EID1836 Meta-analysis of prostate cancer with sixteen case-control studies including 50,048 cases and 123,211 controls. In a random effect model the pooled OR (3.38 (95% CI: 2.45–4.66)) of the studies suppor… (full text at CIViC) PMID 27626483 · Zhang et al., 2016 · Open in CIViC

Cohorts

Alteration frequency by cohort (20)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved20 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Bladder Cancer (Columbia University/MSK, Cell 2018) bladder_columbia_msk_2018	unmapped	Ssm	5	130	3.8%

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.
· Cancer Epidemiol Biomarkers Prev · 2015 · PMID 26108461 · validated civic_curation pubmed
Association between germline homeobox B13 (HOXB13) G84E allele and prostate cancer susceptibility: a meta-analysis and trial sequential analysis.
· Oncotarget · 2016 · PMID 27626483 · validated civic_curation pubmed