Variant · Snv

HOXB13 G84E

CI-VAR-00001840Explore in graph →NP_006352.2:p.Gly84GluNM_006361.5:c.251G>AClinVar 128031 CIViC 772 rs138213197

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Prostate Neoplasm2
HOXB13 G84E	(predisposing)	Predisposing	B	Supports Predisposition	4	accepted	EID1760 G84E (rs138213197) substitution in HOXB13 is associated with an increased risk for prostate cancer. 49 out of 9012 male patients in the Mayo Clinic Biobank were carriers. 31% of patients were diagnose… (full text at CIViC) PMID 26108461 · Beebe-Dimmer et al., 2015 · Open in CIViC	civic
HOXB13 G84E	(predisposing)	Predisposing	B	Supports Predisposition	4	accepted	EID1836 Meta-analysis of prostate cancer with sixteen case-control studies including 50,048 cases and 123,211 controls. In a random effect model the pooled OR (3.38 (95% CI: 2.45–4.66)) of the studies suppor… (full text at CIViC) PMID 27626483 · Zhang et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
128031	Pathogenic/Likely pathogenic; association	criteria provided, multiple submitters, no conflicts	2	Prostate cancer susceptibility; Hereditary cancer-predisposing syndrome; Prostate cancer, hereditary, 9; Carcinoma of pancreas; Familial prostate cancer; Breast and/or ovarian cancer; HOXB13-Related Cancer Predisposition; HOXB13-related disorder	germline	35	Feb 03, 2026