Gene

GATA2

GATA binding protein 2

Explore in graph →CI-GENE-00002798HGNC:4171 ENSG00000179348 NCBI 2624 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
GATA2 EXPRESSION1
Bortezomib + FasudilCombination	Lung Adenocarcinoma	Predictive	D	Supports Sensitivity Response	4	accepted	EID301 Targeting overactive GATA2-mediated pathways with inhibitors bortezomib and fasudil led to dramatic tumor regression. PMID 22541434 · Kumar et al., 2012 · Open in CIViC	civic
GATA2 Mutation1
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Better Outcome	3	submitted	EID8343 GATA2 ZF1 mutations are associated with distinct clinico-biological features and predict better prognosis, different from zinc finger 1 mutations, in AML patients. ZF1 mutations were closely associate…

Cohorts

Alteration frequency by cohort (55)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved55 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	15	103

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
· Cell · 2012 · PMID 22541434 · validated civic_curation pubmed