Publication
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
Authors not recorded
Cell2012PMID 22541434stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerLung Adenocarcinomacivic_curation1.00
- drugBortezomibcivic_curation1.00
- drugFasudilcivic_curation1.00
- geneGATA2civic_curation1.00
- variantGATA2 EXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22541434
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GATA2 EXPRESSION1 | ||||||||
| Bortezomib + FasudilCombination | Lung Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID301Targeting overactive GATA2-mediated pathways with inhibitors bortezomib and fasudil led to dramatic tumor regression. PMID 22541434 · Kumar et al., 2012 · Open in CIViC | civic |