Variant · Snv
FOXL2 C134W
CI-VAR-00000270Explore in graph →CIViC 198
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20693978
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Granulosa Cell Tumor1 | ||||||||
| FOXL2 C134W | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID479FOXL2 C134W mutation was found in 52 / 56 adult granulosa cell tumors, and is absent in other types of sex-cord stromal tumors, and juvenile granulosa tumors. PMID 20693978 · Jamieson et al., 2010 · Open in CIViC | civic |
| Ovarian Sex Cord-Stromal Tumor1 | ||||||||
| FOXL2 C134W | (diagnostic) | Diagnostic | A | Supports Positive | 5 | accepted | EID6034FOXL2 mutations were found in 94% of pathologically confirmed A-GCTs (95/101), in one of eight juvenile granulosa cell tumours (J-GCTs), and in two of 19 SLCTs. PMID 26033501 · Goulvent et al., 2016 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available