Publication
The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.
Authors not recorded
Mod Pathol2010PMID 20693978stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerGranulosa Cell Tumorcivic_curation1.00
- geneFOXL2civic_curation1.00
- variantFOXL2 C134Wcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20693978
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FOXL2 C134W1 | ||||||||
| (diagnostic) | Granulosa Cell Tumor | Diagnostic | B | Supports Positive | 4 | accepted | EID479FOXL2 C134W mutation was found in 52 / 56 adult granulosa cell tumors, and is absent in other types of sex-cord stromal tumors, and juvenile granulosa tumors. PMID 20693978 · Jamieson et al., 2010 · Open in CIViC | civic |