Gene

ERCC5

ERCC excision repair 5, endonuclease

Explore in graph →CI-GENE-00044919HGNC:3437 ENSG00000134899 NCBI 2073 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERCC2 Mutation + ERCC3 Mutation + ERCC4 Mutation + ERCC5 MutationERCC2 ERCC3 ERCC4 ERCC53
(prognostic)	Malignant NeoplasmALIAS	Prognostic	B	Supports Better Outcome	2	submitted	EID12645 In two independent retrospective pan-cancer cohorts without ICI treatment (TCGA cohort 1 n = 3292; MSK-MET cohort 2 n = 25,659), tumors harboring ERCC2/ERCC3/ERCC4/ERCC5 mutations showed improved OS v… (full text at CIViC) PMID 37626083 · Chen et al., 2023 · Open in CIViC	civic
Immune Checkpoint Inhibitor	Melanoma	Predictive	B	Supports Sensitivity Response	3	submitted

Cohorts

Alteration frequency by cohort (87)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved87 cohort rows (showing 37, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Adenocarcinoma (MSK, J Thorac Oncol 2020) luad_mskcc_2020	Lung Adenocarcinoma	Ssm	10

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
· Genes Dev · 2015 · PMID 26338418 · validated civic_curation pubmed

ERCC5 RS7514021
(prognostic)	Parietal Lobe EpendymomaUNRESOLVED	Prognostic	B	Supports Poor Outcome	3	accepted	EID665 The rs751402 polymorphism in the 5' UTR of ERCC5 was correlated with reduced progression free-survival in children with ependymoma that had been treated with platinum-based therapies. 55 post-operativ… (full text at CIViC) PMID 26338418 · Somers et al., 2015 · Open in CIViC	civic

ERCC5 RS7514021

(prognostic)

Parietal Lobe EpendymomaUNRESOLVED

Prognostic

Supports Poor Outcome

accepted

EID665

The rs751402 polymorphism in the 5' UTR of ERCC5 was correlated with reduced progression free-survival in children with ependymoma that had been treated with platinum-based therapies. 55 post-operativ… (full text at CIViC)

PMID 26338418 · Somers et al., 2015 · Open in CIViC

civic