Gene

ERCC4

ERCC excision repair 4, endonuclease catalytic subunit

Explore in graph →CI-GENE-00044918HGNC:3436 ENSG00000175595 NCBI 2072 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERCC2 Mutation + ERCC3 Mutation + ERCC4 Mutation + ERCC5 MutationERCC2 ERCC3 ERCC4 ERCC53
(prognostic)	Malignant NeoplasmALIAS	Prognostic	B	Supports Better Outcome	2	submitted	EID12645 In two independent retrospective pan-cancer cohorts without ICI treatment (TCGA cohort 1 n = 3292; MSK-MET cohort 2 n = 25,659), tumors harboring ERCC2/ERCC3/ERCC4/ERCC5 mutations showed improved OS v… (full text at CIViC) PMID 37626083 · Chen et al., 2023 · Open in CIViC	civic
Immune Checkpoint Inhibitor	Melanoma	Predictive	B	Supports Sensitivity Response	3	submitted

Cohorts

Alteration frequency by cohort (68)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved68 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017	Lung Small Cell Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.