Variant · Expression
CXCR4 EXPRESSION
CI-VAR-00000932Explore in graph →CIViC 405
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20651371
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Gastric Adenocarcinoma1 | ||||||||
| CXCR4 EXPRESSION | Docetaxel | Predictive | B | Supports Resistance | 2 | accepted | EID949CXCR4 expression as assessed by microarray analysis, was associated with resistance to docetaxel in 11 cancer cell lines (R^2 = 0.23, p = 0.019). Expression levels (by qtPCR) were also higher in resis… (full text at CIViC) PMID 20651371 · Xie et al., 2010 · Open in CIViC | civic |
| Lung Non-Small Cell Carcinoma1 | ||||||||
| CXCR4 EXPRESSION | Cisplatin | Predictive | D | Supports Resistance | 3 | submitted | EID2912CXCR4, a stromal-derived-factor-1 specific chemokine receptor, is highly expressed in non-small cell lung cancer (NSCLC) tissues and participates in cancer progression by regulating cell growth, apopt… (full text at CIViC) PMID 27922681 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available