Gene

ATR

ATR checkpoint kinase

Explore in graph →CI-GENE-00021455HGNC:882 ENSG00000175054 NCBI 545 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATR I774FS1
(prognostic)	Malignant Endometrial NeoplasmCURATED_BROADER	Prognostic	B	Supports Poor Outcome	4	accepted	EID690 Extension and reduction of the ATR exon 10 A10 repeat (alters codon I774) was associated with poorer overall and disease-free survival in patients with endometrioid endometrial cancer when compared to… (full text at CIViC) PMID 19470935 · Zighelboim et al., 2009 · Open in CIViC	civic
ATR Loss-of-function1
Enzalutamide + TalazoparibCombination	Castration-Resistant Prostate Carcinoma	Predictive	A	Supports Sensitivity Response	2	submitted

Cohorts

Alteration frequency by cohort (178)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved178 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Cancer (MSK, Cell Metab 2020) prad_msk_2019	unmapped	Ssm	1	18	5.6%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.
· J Clin Oncol · 2009 · PMID 19470935 · validated civic_curation pubmed