Gene

ASNS

asparagine synthetase (glutamine-hydrolyzing)

Explore in graph →CI-GENE-00011548HGNC:753 ENSG00000070669 NCBI 440 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ASNS Amplification1
Asparaginase	Malignant Ovarian Neoplasm	Predictive	D	Supports Resistance	2	accepted	EID953 ASNS amplification and expression was associated with resistance to L-asparaginase in ovarian cancer and leukemia cell lines. ASNS silencing increased sensitivity to l-ASP in 2/3 of ovarian cancer cel… (full text at CIViC) PMID 17088436 · Lorenzi et al., 2006 · Open in CIViC	civic
ASNS Fusion1
Asparaginase	T Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Predictive	D	Supports Resistance	3	submitted	EID5926 Fusion of the KMT2E promoter with the complete coding sequence of ASNS was observed in two relapsed ETP-ALL patients treated with l-asparaginase. The variant was shown to significantly increase ASNS e…

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Nasopharyngeal Carcinoma (Singapore, Nat Genet 2014) npc_nusingapore	Nasopharyngeal Carcinoma	Ssm	1	56

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
· Mol Cancer Ther · 2006 · PMID 17088436 · validated civic_curation pubmed