Precursor Condition
Squamous Cell Intraepithelial Neoplasia
CI-CAN-00001551SIL · SINExplore in graph →
Precursor19 active trials
- NCIt
- C8334
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Precursor Condition
CI-CAN-00001551SIL · SINExplore in graph →
Clinical trials
115 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06949800 | CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial | recruiting | Phase 2 | 90 | University of California, San FranciscoOTHER | 2 | Sep 15, 2026 | clinicaltrials |
| NCT07793552 | Needlefree Lidocaine Application for Vulvar Biopsies | not yet recruiting | N/A | 106 | Tufts Medical CenterOTHER | 1 | Aug 28, 2026 | clinicaltrials |
| NCT05074264 |
| Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico(CAMPO-101) |
| active not recruiting |
| N/A |
| 1,586 |
| University of California, San FranciscoOTHER |
| 2 |
| Aug 24, 2026 |
| clinicaltrials |
| NCT06233331 | Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV | not yet recruiting | Phase 1 | 9 | Emory UniversityOTHER | 1 | Aug 18, 2026 | clinicaltrials |
| NCT05463796 | InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer | recruiting | — | 5,000 | Dana-Farber Cancer InstituteOTHER | 1 | Aug 17, 2026 | clinicaltrials |
| NCT02698293 | PDT Plus Vitamin D3 for Anal Dysplasia | withdrawn | Phase 1 | 0 | Abramson Cancer Center at Penn MedicineOTHER | 1 | Aug 4, 2026 | clinicaltrials |
| NCT05028725 | Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma | recruiting | N/A | 289 | University of California, San FranciscoOTHER | 1 | Jul 23, 2026 | clinicaltrials |
| NCT03603808 | VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions | completed | Phase 2 | 44 | AIDS Malignancy ConsortiumNETWORK | 2 | Jul 8, 2026 | clinicaltrials |
| NCT06979180 | A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV. | recruiting | N/A | 60 | Papillex Inc.INDUSTRY | 1 | Jul 8, 2026 | clinicaltrials |
| NCT03913117 | Study of Treatment for HPV16+ ASC-US or LSIL(PVX-6) | recruiting | Phase 1 | 30 | University of Alabama at BirminghamOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT05334004 | Lopinavir/Ritonavir in PLWH With High-Grade AIN | recruiting | Phase 1 | 21 | University of Wisconsin, MadisonOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT07572396 | Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities | recruiting | Phase 2 | 45 | Amplexd Therapeutics, Inc.INDUSTRY | 1 | May 14, 2026 | clinicaltrials |
| NCT07029152 | Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis(SCOPE) | recruiting | N/A | 296 | Universitair Ziekenhuis BrusselOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT06971276 | Assessing the Utility of Plasma ctHPVDNA for Anal Cancer Screening(SCAN-LITE) | completed | — | 104 | Massachusetts Eye and Ear InfirmaryOTHER | 1 | Apr 28, 2026 | clinicaltrials |
| NCT07480902 | Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer | recruiting | N/A | 558 | Timser SAPI de CVINDUSTRY | 1 | Mar 18, 2026 | clinicaltrials |
| NCT04712851 | Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia | recruiting | Phase 2 | 25 | Jonsson Comprehensive Cancer CenterOTHER | 1 | Mar 10, 2026 | clinicaltrials |
| NCT07211204 | Comparison Of Cytology And Molecular Screening For Detecting Cervical Reactive Cellular Changes In General Population | withdrawn | N/A | 0 | Timser SAPI de CVINDUSTRY | 1 | Mar 3, 2026 | clinicaltrials |
| NCT03284866 | HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV(COVENANT) | completed | Phase 3 | 536 | AIDS Malignancy ConsortiumNETWORK | 5 | Jan 28, 2026 | clinicaltrials |
| NCT07306260 | Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2(PDT for CIN2) | not yet recruiting | N/A | 560 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Dec 29, 2025 | clinicaltrials |
| NCT06075264 | Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3)(ART-VIN IIB) | recruiting | Phase 2 | 27 | Frantz Viral Therapeutics, LLCINDUSTRY | 1 | Aug 14, 2025 | clinicaltrials |
| NCT02534233 | Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium(ColdPlay2) | completed | N/A | 58 | Johns Hopkins UniversityOTHER | 1 | Aug 1, 2025 | clinicaltrials |
| NCT06866574 | A Phase III Trial to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) in Chinese Males | active not recruiting | Phase 3 | 9,300 | Xiamen UniversityOTHER | 1 | Jul 31, 2025 | clinicaltrials |
| NCT05104099 | Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia(PhotodiVIN) | completed | Phase 2 | 17 | Institut de Cancérologie de LorraineOTHER | 1 | Jul 24, 2025 | clinicaltrials |
| NCT02059499 | Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions | completed | Phase 3 | 91 | AIDS Malignancy ConsortiumNETWORK | 2 | Jul 23, 2025 | clinicaltrials |
| NCT02140021 | Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer | terminated | N/A | 409 | M.D. Anderson Cancer CenterOTHER | 1 | Jul 14, 2025 | clinicaltrials |
| NCT05555862 | Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL(anal HSIL HIV-) | active not recruiting | Phase 2 | 17 | Frantz Viral Therapeutics, LLCINDUSTRY | 1 | May 18, 2025 | clinicaltrials |
| NCT03061435 | Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.(Vulvar-AIN) | recruiting | N/A | 110 | Dr. Danielle VicusOTHER | 1 | May 16, 2025 | clinicaltrials |
| NCT05266898 | Immunogenicity of Gardasil-9 HPV Vaccine in People Living With HIV(AGO-Gard) | recruiting | Phase 4 | 250 | Louisiana State University Health Sciences Center in New OrleansOTHER | 1 | Apr 18, 2025 | clinicaltrials |
| NCT03267680 | IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3 | terminated | Phase 2 | 10 | University of Southern CaliforniaOTHER | 1 | Apr 13, 2025 | clinicaltrials |
| NCT03196180 | Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia | completed | Early Phase 1 | 13 | National Cancer Institute (NCI)NIH | 1 | Apr 8, 2025 | clinicaltrials |
| NCT04276935 | Development of a Health-Related Symptom Index for Participants With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions | completed | — | 20 | AIDS Malignancy ConsortiumNETWORK | 1 | Mar 7, 2025 | clinicaltrials |
| NCT05717621 | Clinical Trial With Local Decitabine Treatment of HPV-Induced VIN Grade 2/3 (DelVIN)(DelVIN) | completed | Phase 1 | 29 | ViMREX GmbHINDUSTRY | 1 | Feb 11, 2025 | clinicaltrials |
| NCT06713655 | Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation | not yet recruiting | — | 800 | Women's Hospital School Of Medicine Zhejiang UniversityOTHER | 1 | Dec 6, 2024 | clinicaltrials |
| NCT03792516 | Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3)(ART-VIN) | completed | Phase 1 | 15 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Dec 4, 2024 | clinicaltrials |
| NCT03721978 | REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL) | completed | Phase 3 | 203 | Inovio PharmaceuticalsINDUSTRY | 10 | Oct 17, 2024 | clinicaltrials |
| NCT05282095 | Effect of HPV Integration on Prognosis of Young Women With CIN2 in China | recruiting | — | 300 | Fujian Maternity and Child Health HospitalOTHER | 1 | Sep 19, 2024 | clinicaltrials |
| NCT06297187 | Cavitronic Ultrasonic Surgical Aspiration (CUSA) Women's Health Study | completed | — | 56 | Integra LifeSciences CorporationINDUSTRY | 1 | Sep 19, 2024 | clinicaltrials |
| NCT02135419 | Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions(ANCHOR) | completed | Phase 3 | 4,446 | AIDS Malignancy ConsortiumNETWORK | 2 | Jul 26, 2024 | clinicaltrials |
| NCT04055142 | Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males(TreatAIN) | completed | Phase 3 | 108 | Hospital Universitari Vall d'Hebron Research InstituteOTHER | 1 | Jul 10, 2024 | clinicaltrials |
| NCT03911076 | Phase II Study of Treatment for HPV16+ ASC-US, ASC-H and LSIL(PVX2) | terminated | Phase 2 | 16 | PapiVax Biotech, Inc.OTHER | 1 | Jun 17, 2024 | clinicaltrials |
| NCT04422366 | Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females | recruiting | Phase 3 | 8,000 | Shanghai Bovax Biotechnology Co., Ltd.INDUSTRY | 1 | Jun 7, 2024 | clinicaltrials |
| NCT04895020 | Immunobridging Study of 9-valent Human Papillomavirus Recombinant Vaccine in Chinese Females Aged 9 to 19 Years | unknown | Phase 3 | 1,200 | Shanghai Bovax Biotechnology Co., Ltd.INDUSTRY | 1 | Apr 17, 2024 | clinicaltrials |
| NCT06327568 | Anal Cancer and/or Precancer Screening: Performance Analysis of the BD Onclarity™ HPV Assay on Anal Specimens | recruiting | — | 200 | European Institute of OncologyOTHER | 1 | Mar 26, 2024 | clinicaltrials |
| NCT03285841 | OCT-AF Imaging of Pre-cancers of Vulva and Cervix | terminated | — | 20 | British Columbia Cancer AgencyOTHER | 1 | Mar 18, 2024 | clinicaltrials |
| NCT03051516 | HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions | terminated | Phase 4 | 188 | Fred Hutchinson Cancer CenterOTHER | 1 | Feb 28, 2024 | clinicaltrials |
| NCT06208319 | Development and Evaluation of an Artificial Intelligence Tool for Colposcopy Assistance(IACOL) | unknown | — | 1,000 | Assistance Publique - Hôpitaux de ParisOTHER | 0 | Feb 1, 2024 | clinicaltrials |
| NCT02735109 | Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors | terminated | N/A | 10 | Centre Hospitalier Universitaire de NiceOTHER | 1 | Jan 26, 2024 | clinicaltrials |
| NCT05613283 | Primary Cervical Cancer Screening by Self-sampling HPV Test(PREVENT) | active not recruiting | — | 17,875 | Peking University People's HospitalOTHER | 1 | Dec 21, 2023 | clinicaltrials |
| NCT02146508 | Endoscopic Prevention of Esophageal Cancer at Tenwek Hospital(EXPECT) | suspended | N/A | 75 | Tenwek HospitalOTHER | 1 | Dec 11, 2023 | clinicaltrials |
Data updated 15 days agoSource updated Sep 15, 2026source: clinicaltrials