Endoscopic Prevention of Esophageal Cancer at Tenwek Hospital

Inclusion Criteria:

* Participant is 18-85 years of age, inclusive
* Participant has had a prior endoscopy with Lugol's chromoendoscopy demonstrating an unstained lesion (USL) of at least 5 mm which on biopsy contained moderate grade dysplasia (MGD), high grade dysplasia (HGD), or esophageal squamous cell cancer (ESCC) of flat mucosa limited to the lamina propria, with no evidence of invasion.
* The maximum allowable linear length of USL-bearing esophagus is 20 cm.
* No more than 14 continuous linear cm of esophagus require treatment for MGD, HGD, or ESCC.
* For patients with ESCC, CT scan of chest and upper third of the abdomen shows no exclusionary findings for the trial, such as metastasis.
* Participant is not pregnant and has no plans to become pregnant in the ensuing 12 months (confirmation of pregnancy status in women of child-bearing age and ability required prior to each endoscopy with urine or blood test, if subject believes she may be pregnant or has missed a menstrual period)
* Participant is eligible for treatment and follow-up endoscopy and biopsy as required by the protocol
* Participant is willing to provide written, informed consent to participate in this clinical study and understands the responsibilities of trial participation

Exclusion Criteria:

* Esophageal stricture preventing passage of a therapeutic endoscope
* Any prior endoscopic resection
* Any esophageal dilation in the past 12 months
* Any history of ESCC of the esophagus, except for ESCC of flat mucosa limited to the lamina propria diagnosed within 12 months of study enrollment.
* In participants with ESCC, any evidence of nodal involvement or distant metastases
* Any previous ablative therapy within the esophagus (photodynamic therapy, multipolar electrical coagulation, argon plasma coagulation, laser treatment, or other) or any radiation therapy to the esophagus.
* Any previous esophageal surgery, except fundoplication
* Evidence of esophageal varices detected within last 6 months or at initial EMR/RFA procedure
* Evidence of eosinophilic esophagitis on endoscopy and/or histology
* History of coagulopathy, or use of warfarin within the past month.
* Report of uncontrolled coagulopathy with international normalized ratio (INR) \> 2 or platelet count \<75,000 platelets per µL (note: laboratory testing is not required for all subjects in this study)
* Participant is using aspirin, clopidogrel, or non-steroidal anti-inflammatory drugs that cannot be discontinued 7 days before and after therapeutic sessions
* Participant has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines
* Participant has an implantable pacing device (examples; automatic implantable cardioverter/defibrillator, neurostimulator, cardiac pacemaker) and has not received clearance for enrollment in this study by the physician responsible for the pacing device
* Participant suffers from psychiatric or other illness deemed by the investigator as an inability to comply with protocol
* Participant has life expectancy less than 2 years