CCNB3 Fusion

CI-VAR-00001303Explore in graph →CIViC 3251

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Clear Cell Sarcoma of the Kidney3
BCOR::CCNB3 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID12003 In this 2018 study, the authors aimed to identify driver events in 'double negative' clear cell sarcoma of the kidney (CCSK) where neither BCOR ITDs nor the YWHAE::NUTM2 gene fusion are detected. Elev… (full text at CIViC) PMID 28833375 · Wong et al., 2018 · Open in CIViC	civic
BCOR::CCNB3 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID12004 In this 2020 study, the authors report two patients with BCOR::CCNB3 fusion-positive clear cell sarcoma of the kidney (CCSK). Cases were males aged 10 and 14 years who presented with advanced disease.… (full text at CIViC) PMID 31876361 · Han et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Sarcoma with BCOR Genetic Alterations4
BCOR::CCNB3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9011 This study consists of a cohort of 42 pediatric and adult patients with sarcomas that were classified as undifferentiated. Six of the forty two patients had BCOR::CCNB3 fusions detected by whole trans… (full text at CIViC) PMID 25360585 · Peters et al., 2015 · Open in CIViC	civic
BCOR::CCNB3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID10111 Kao, et al. (2018) presented 36 BCOR::CCNB3 sarcoma cases (86% were males; mean and median age at presentation was 15 years (range from 2 to 44 years); 78% showed mainly primitive round cells morpholo… (full text at CIViC) PMID 29300189 · Kao et al., 2018 · Open in CIViC	civic
BCOR::CCNB3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12568 In this 2017 study reviewing 753 sarcoma cases, 11 tumors with the BCOR::CCNB3 fusion were identified using immunohistochemistry and RT-PCR. These tumors were found exclusively in males, with a mean a… (full text at CIViC) PMID 28420319 · Ludwig et al., 2017 · Open in CIViC	civic
BCOR::CCNB3 Fusion OR BCOR::MAML3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11590 BCOR expression was evaluated in a cohort of 25 small blue round cell tumors (SBRCTs) with BCOR fusions (BCOR::MAML3, BCOR::CCNB3), BCOR exon 15 ITDs, or YWHAE-NUTM2B fusion (which is known to upregul… (full text at CIViC) PMID 27428733 · Kao et al., 2016 · Open in CIViC	civic