NFATC2 Fusion

CI-VAR-00001386Explore in graph →CIViC 4603

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Round Cell Sarcoma with EWSR1-non-ETS Fusion3
EWSR1::NFATC2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11604 This analysis of small round cell tumors of the bone identified 3 with EWSR1::NFATC2 fusions and 1 with a FUS::NFATC2 fusion. The authors extended their review to an additional 45 cases in the litera… (full text at CIViC) PMID 31078563 · Diaz-Perez et al., 2019 · Open in CIViC	civic
EWSR1::NFATC2 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12590 A small case series examined molecular features along with clinicopathologic and immunohistochemical characteristics of sarcomas with EWSR1::NFATC2 gene fusions. The study included 6 cases (5 males an… (full text at CIViC) PMID 30994538 · Wang et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.