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CancerIndexthe global index of cancer

Cancers Data Trials Drugs Genes Biomarkers Approvals Rankings Research gap Graph

Cancers Data Trials Drugs Genes Biomarkers Approvals Rankings Research gap Graph

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CancerIndex

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Neoplasm of Uncertain Histogenesis — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Neoplasm of Uncertain Histogenesis

Cancer

Neoplasm of Uncertain Histogenesis

CI-CAN-00000034Explore in graph →

Non-malignant20,280 active trials259 approved drugs3,813 evidence items

NCIt: C6974
OncoTree: MBT
UMLS CUI: C1334936

Overview
Statistics
Survival
Genomics465
Variants & evidence3813
Drugs427
Trials91351
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (4,399)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 4,101–4,125 of 4,399 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
· Blood · 2006 · PMID 16690963 · validated civic_curation pubmed
Crizotinib, a c-Met inhibitor, prevents metastasis in a metastatic uveal melanoma model.
· Mol Cancer Ther · 2013 · PMID 24140933 · validated civic_curation pubmed
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
· N Engl J Med · 2012 · PMID 22931316 · validated civic_curation pubmed
Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL.
· Anticancer Drugs · 2016 · PMID 27276402 · validated civic_curation pubmed
Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines.
· PLoS One · 2016 · PMID 26751376 · validated civic_curation pubmed
Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.
· Oncotarget · 2016 · PMID 27612423 · validated civic_curation pubmed
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.
· Sci Signal · 2010 · PMID 21098728 · validated civic_curation pubmed

Showing 4,101–4,125 of 4,399 publications

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Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.

· Clin Cancer Res · 2008 · PMID 18927303 · validated civic_curation pubmed

Targeting Akt3 signaling in triple-negative breast cancer.

· Cancer Res · 2014 · PMID 24335962 · validated civic_curation pubmed

The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.

· Mol Cancer Ther · 2012 · PMID 22302096 · validated civic_curation pubmed

Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.

· Cancer · 2012 · PMID 22252991 · validated civic_curation pubmed

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

· Cell · 2010 · PMID 20141835 · validated civic_curation pubmed

Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients.

· Clin Cancer Res · 2000 · PMID 11051239 · validated civic_curation pubmed

The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns.

· Blood · 2019 · PMID 31434706 · validated civic_curation pubmed

Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia.

· Blood Cancer J · 2014 · PMID 24927407 · validated civic_curation pubmed

Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.

· Am J Pathol · 2013 · PMID 23506848 · validated civic_curation pubmed

Epiregulin is required for lung tumor promotion in a murine two-stage carcinogenesis model.

· Mol Carcinog · 2017 · PMID 26894620 · validated civic_curation pubmed

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

· Genes Dev · 2016 · PMID 27034505 · validated civic_curation pubmed

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.

· Oncotarget · 2015 · PMID 25970771 · validated civic_curation pubmed

ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.

· Mol Cancer Res · 2014 · PMID 24296758 · validated civic_curation pubmed

Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.

· Cancer Res · 2014 · PMID 24253377 · validated civic_curation pubmed

Association between PD-L1 expression and driven gene status in NSCLC: A meta-analysis.

· Eur J Surg Oncol · 2017 · PMID 28259530 · validated civic_curation pubmed

Primary and Metastatic Melanoma With NTRK Fusions.

· Am J Surg Pathol · 2018 · PMID 29683819 · validated civic_curation pubmed

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.

· Cancer Discov · 2018 · PMID 29196463 · validated civic_curation pubmed

A systematic profile of clinical inhibitors responsive to EGFR somatic amino acid mutations in lung cancer: implication for the molecular mechanism of drug resistance and sensitivity.

· Amino Acids · 2014 · PMID 24658966 · validated civic_curation pubmed