Publication
The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerEsophageal Adenocarcinomacivic_curation1.00
- drugAlisertibcivic_curation1.00
- drugCisplatincivic_curation1.00
- geneAURKAcivic_curation1.00
- variantAURKA Amplificationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22302096
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AURKA Amplification1 | ||||||||
| Alisertib + CisplatinCombination | Esophageal AdenocarcinomaALIAS | Predictive | E | Supports Sensitivity Response | 3 | accepted | EID456Antitumour effect of alisertib treatment in esophageal adenocarcinomas can be intensified in combination with cisplatin. PMID 22302096 · Sehdev et al., 2012 · Open in CIViC | civic |
| AURKA Overexpression1 | ||||||||
| Alisertib + CisplatinCombination | Esophageal AdenocarcinomaALIAS | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID9627The efficacy of novel AURKA inhibitor alisertib (MLN8327) was tested alone or in combination with cisplatin in three esophageal adenocarcinoma cell lines (FLO-1, OE19 and OE33) that overexpress AURKA.… (full text at CIViC) PMID 22302096 · Sehdev et al., 2012 · Open in CIViC | civic |