Cancer Family
Myeloid Neoplasm
CI-CAN-00000279Explore in graph →
HematologicNon-malignant1,102 active trials29 approved drugs653 evidence items
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Cancer Family
CI-CAN-00000279Explore in graph →
Genomics
22 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
4,231 cases with simple somatic mutation data · 4,231 cases total · 2026-01-08 · mapped to Myelodysplastic Syndrome EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | DNMT3A |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 853 |
| 4,231 |
| 20.2% |
| cbioportal |
| 2 | TET2 | Ssm | 683 | 4,231 | 16.1% | cbioportal |
| 3 | NPM1 | Ssm | 674 | 4,231 | 15.9% | cbioportal |
| 4 | NRAS | Ssm | 492 | 4,231 | 11.6% | cbioportal |
| 5 | FLT3 | Ssm | 475 | 4,231 | 11.2% | cbioportal |
| 6 | ASXL1 | Ssm | 434 | 4,231 | 10.3% | cbioportal |
| 7 | SRSF2 | Ssm | 415 | 4,231 | 9.8% | cbioportal |
| 8 | RUNX1 | Ssm | 408 | 4,231 | 9.6% | cbioportal |
| 9 | TP53 | Ssm | 399 | 4,231 | 9.4% | cbioportal |
| 10 | SF3B1 | Ssm | 378 | 4,231 | 8.9% | cbioportal |
| 11 | IDH2 | Ssm | 359 | 4,231 | 8.5% | cbioportal |
| 12 | JAK2 | Ssm | 336 | 4,231 | 7.9% | cbioportal |
| 33 | MUC4 | Ssm | 69 | 1,026 | 6.7% | cbioportal |
| 13 | IDH1 | Ssm | 263 | 4,231 | 6.2% | cbioportal |
| 35 | NBPF10 | Ssm | 59 | 1,026 | 5.8% | cbioportal |
| 14 | PTPN11 | Ssm | 217 | 4,231 | 5.1% | cbioportal |
| 15 | U2AF1 | Ssm | 202 | 4,231 | 4.8% | cbioportal |
| 40 | MUC12 | Ssm | 47 | 1,026 | 4.6% | cbioportal |
| 16 | CEBPA | Ssm | 193 | 4,231 | 4.6% | cbioportal |
| 17 | STAG2 | Ssm | 188 | 4,231 | 4.4% | cbioportal |
| 18 | KRAS | Ssm | 184 | 4,231 | 4.3% | cbioportal |
| 19 | WT1 | Ssm | 179 | 4,231 | 4.2% | cbioportal |
| 20 | EZH2 | Ssm | 170 | 4,231 | 4% | cbioportal |
| 21 | BCOR | Ssm | 157 | 4,231 | 3.7% | cbioportal |
| 48 | MUC2 | Ssm | 38 | 1,026 | 3.7% | cbioportal |
| 47 | FCGBP | Ssm | 38 | 1,026 | 3.7% | cbioportal |
| 49 | NBPF1 | Ssm | 37 | 1,026 | 3.6% | cbioportal |
| 52 | HRNR | Ssm | 34 | 1,026 | 3.3% | cbioportal |
| 31 | CALR | Ssm | 72 | 2,268 | 3.2% | cbioportal |
| 22 | CBL | Ssm | 134 | 4,231 | 3.2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-08