Cancer
Malignant Liver Neoplasm
CI-CAN-00003177Explore in graph →
Top-level906 active trials14 approved drugs17 evidence items
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Cancer
CI-CAN-00003177Explore in graph →
Genomics
19 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,370 cases with simple somatic mutation data · 1,370 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 466 |
| 1,370 |
| 34% |
| cbioportal |
| 2 | ARID1A | Ssm | 226 | 1,370 | 16.5% | cbioportal |
| 3 | TERT | Ssm | 225 | 1,370 | 16.4% | cbioportal |
| 4 | KRAS | Ssm | 152 | 1,370 | 11.1% | cbioportal |
| 5 | IDH1 | Ssm | 141 | 1,370 | 10.3% | cbioportal |
| 6 | CTNNB1 | Ssm | 132 | 1,370 | 9.6% | cbioportal |
| 7 | BAP1 | Ssm | 117 | 1,370 | 8.5% | cbioportal |
| 85 | ALB | Ssm | 18 | 221 | 8.1% | cbioportal |
| 8 | SMAD4 | Ssm | 103 | 1,370 | 7.5% | cbioportal |
| 9 | PBRM1 | Ssm | 95 | 1,370 | 6.9% | cbioportal |
| 10 | ATM | Ssm | 74 | 1,370 | 5.4% | cbioportal |
| 11 | KMT2C | Ssm | 69 | 1,370 | 5% | cbioportal |
| 12 | ARID2 | Ssm | 67 | 1,370 | 4.9% | cbioportal |
| 13 | PIK3CA | Ssm | 67 | 1,370 | 4.9% | cbioportal |
| 18 | ELF3 | Ssm | 47 | 998 | 4.7% | cbioportal |
| 14 | KMT2D | Ssm | 64 | 1,370 | 4.7% | cbioportal |
| 15 | CDKN2A | Ssm | 62 | 1,370 | 4.5% | cbioportal |
| 16 | BRAF | Ssm | 52 | 1,370 | 3.8% | cbioportal |
| 32 | PREX2 | Ssm | 35 | 998 | 3.5% | cbioportal |
| 17 | NF1 | Ssm | 48 | 1,370 | 3.5% | cbioportal |
| 20 | RB1 | Ssm | 44 | 1,370 | 3.2% | cbioportal |
| 19 | ERBB3 | Ssm | 44 | 1,370 | 3.2% | cbioportal |
| 21 | KMT2A | Ssm | 42 | 1,370 | 3.1% | cbioportal |
| 24 | STK11 | Ssm | 41 | 1,370 | 3% | cbioportal |
| 23 | FGFR2 | Ssm | 41 | 1,370 | 3% | cbioportal |
| 22 | APC | Ssm | 41 | 1,370 | 3% | cbioportal |
| 41 | KMT2B | Ssm | 29 | 998 | 2.9% | cbioportal |
| 28 | ZFHX3 | Ssm | 37 | 1,284 | 2.9% | cbioportal |
| 25 | AXIN1 | Ssm | 39 | 1,370 | 2.8% | cbioportal |
| 27 | RASA1 | Ssm | 37 | 1,370 | 2.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07