Subtype
Malignant Large Intestinal Neoplasm
CI-CAN-00003173Explore in graph →
1,622 active trials21 approved drugs383 evidence items
- NCIt
- C215202
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Subtype
CI-CAN-00003173Explore in graph →
Clinical trials
7,500 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (742)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02394795 | Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC(PARADIGM) | completed | Phase 3 | 823 | TakedaINDUSTRY | 1 | Nov 1, 2023 | clinicaltrials |
| NCT02551237 | Neoadjuvant Treatment for Advanced Rectal Carcinoma(NACRE) | completed | Phase 3 | 103 | UNICANCEROTHER | 1 | Oct 13, 2023 | clinicaltrials |
| NCT01606098 |
| The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer(CAIRO4) |
| completed |
| Phase 3 |
| 206 |
| Dutch Colorectal Cancer GroupOTHER |
| 2 |
| Sep 13, 2023 |
| clinicaltrials |
| NCT01830621 | BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma | completed | Phase 3 | 282 | NCIC Clinical Trials GroupNETWORK | 3 | Aug 28, 2023 | clinicaltrials |
| NCT00079066 | Cetuximab + Best Supportive Care Compared With Best Supportive Care Alone in Metastatic Epidermal Growth Factor Receptor-Positive Colorectal Cancer | completed | Phase 3 | 572 | NCIC Clinical Trials GroupNETWORK | 2 | Aug 4, 2023 | clinicaltrials |
| NCT00640471 | Cetuximab With or Without Brivanib in Treating Patients With K-Ras Wild Type Tumours and Metastatic Colorectal Cancer | completed | Phase 3 | 750 | NCIC Clinical Trials GroupNETWORK | 1 | Aug 4, 2023 | clinicaltrials |
| NCT00979680 | Sphincter-preserving Surgery After Preoperative Treatment of Ultra-low Rectal Carcinoma(GRECCAR1) | completed | Phase 3 | 207 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 1 | Jun 29, 2023 | clinicaltrials |
| NCT00003057 | Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer | completed | Phase 3 | 500 | Eastern Cooperative Oncology GroupNETWORK | 1 | Jun 18, 2023 | clinicaltrials |
| NCT00202774 | Safety and Efficacy Study of XELOX vs. Oxaliplatin+5-FU CI as First Line Treatment in Metastatic Colorectal Cancer | completed | Phase 3 | 348 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)OTHER | 1 | Apr 12, 2023 | clinicaltrials |
| NCT01718873 | Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer(OBELICS) | completed | Phase 3 | 230 | National Cancer Institute, NaplesOTHER | 1 | Apr 12, 2023 | clinicaltrials |
| NCT03231722 | First Line mFOLFOXIRI + PANITUMUMAB vs mFOLFOX + PANITUMUMAB IN RAS AND BRAF WT METASTATIC COLORECTAL CANCER PATIENTS(TRIPLETE) | completed | Phase 3 | 435 | Gruppo Oncologico del Nord-OvestOTHER | 1 | Jan 5, 2023 | clinicaltrials |
| NCT00642577 | A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer. | completed | Phase 3 | 214 | Hoffmann-La RocheINDUSTRY | 1 | Dec 22, 2022 | clinicaltrials |
| NCT02870582 | Donafenib for Previously Treated Metastatic Colorectal Cancer | completed | Phase 3 | 536 | Suzhou Zelgen Biopharmaceuticals Co.,LtdINDUSTRY | 1 | Nov 29, 2022 | clinicaltrials |
| NCT00113763 | Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer | completed | Phase 3 | 463 | AmgenINDUSTRY | 0 | Nov 7, 2022 | clinicaltrials |
| NCT00364013 | PRIME: Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy | completed | Phase 3 | 1,183 | AmgenINDUSTRY | 0 | Nov 7, 2022 | clinicaltrials |
| NCT01099449 | Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy | completed | Phase 3 | 362 | Alliance for Clinical Trials in OncologyOTHER | 2 | Nov 3, 2022 | clinicaltrials |
| NCT00339183 | Comparison of Treatment Effect of Chemotherapy With Panitumumab to Chemotherapy Alone | completed | Phase 3 | 1,186 | AmgenINDUSTRY | 0 | Sep 23, 2022 | clinicaltrials |
| NCT01001377 | ASPECCT: A Study of Panitumumab Efficacy and Safety Compared to Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer | completed | Phase 3 | 1,010 | AmgenINDUSTRY | 29 | Sep 21, 2022 | clinicaltrials |
| NCT01648894 | Influence of Lengthening the Interval Between Radiochemotherapy and Surgery on Complete Pathological Response in Rectal Cancer(GRECCAR6) | completed | Phase 3 | 265 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Jul 25, 2022 | clinicaltrials |
| NCT00389870 | Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil | completed | Phase 3 | 1,198 | University of LeedsOTHER | 1 | Jun 1, 2022 | clinicaltrials |
| NCT00995202 | Follow-Up Care With or Without CEA Assessments in Patients Who Have Undergone Surgery for Stage II or Stage III Colorectal Cancer(SURVEILLANCE) | completed | Phase 3 | 1,997 | Federation Francophone de Cancerologie DigestiveOTHER | 3 | Dec 7, 2021 | clinicaltrials |
| NCT01308190 | Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer | completed | Phase 3 | 173 | Corporacion Parc TauliOTHER | 1 | Nov 23, 2021 | clinicaltrials |
| NCT00070213 | Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer | completed | Phase 3 | 460 | Medical Research CouncilOTHER_GOV | 1 | Sep 27, 2021 | clinicaltrials |
| NCT01927497 | Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer(BIOPEX) | completed | Phase 3 | 104 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)OTHER | 1 | Aug 17, 2021 | clinicaltrials |
| NCT02909478 | Aprepitant Without Steroid in Preventing Chemotherapy-induced Nausea and Vomiting in Patients With Colorectal Cancer | completed | Phase 3 | 315 | Sun Yat-sen UniversityOTHER | 1 | Jul 29, 2021 | clinicaltrials |
| NCT01455831 | Extended Peri-operative Tinzaparin to Improve Disease-free Survival in Patients With Resectable Colorectal Cancer(PERIOP-01) | completed | Phase 3 | 616 | Ottawa Hospital Research InstituteOTHER | 3 | May 17, 2021 | clinicaltrials |
| NCT02138422 | A Phase 3 Study to Evaluate Xilonix as an Anticancer Therapy in Patients With Symptomatic Colorectal Cancer | completed | Phase 3 | 276 | Janssen Research & Development, LLCINDUSTRY | 1 | Mar 1, 2021 | clinicaltrials |
| NCT00003652 | Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer | completed | Phase 3 | 350 | UNICANCEROTHER | 1 | Feb 17, 2021 | clinicaltrials |
| NCT00005979 | Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer | completed | Phase 3 | — | UNICANCEROTHER | 1 | Feb 17, 2021 | clinicaltrials |
| NCT00227747 | Radiation Therapy and Capecitabine With or Without Oxaliplatin in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Rectal Cancer | completed | Phase 3 | 598 | UNICANCEROTHER | 1 | Feb 17, 2021 | clinicaltrials |
| NCT03031444 | Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasis(PARECEC) | completed | Phase 2 / Phase 3 | 135 | Peking University Cancer Hospital & InstituteOTHER | 1 | Feb 1, 2021 | clinicaltrials |
| NCT03288987 | Comparing Efficacy and Safety of Stivant (AryoGen Bevacizumab) Versus Avastin in Metastatic Colorectal Cancer | completed | Phase 3 | 126 | AryoGen Pharmed Co.INDUSTRY | 1 | Jan 22, 2021 | clinicaltrials |
| NCT01224392 | Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer(RectumSIB) | completed | Phase 3 | 156 | Universitair Ziekenhuis BrusselOTHER | 1 | Dec 30, 2020 | clinicaltrials |
| NCT01500993 | Capecitabine in the Perioperative Treatment of Rectal Cancer(Rektum-III) | completed | Phase 3 | 401 | Universitätsmedizin MannheimOTHER | 1 | Nov 27, 2020 | clinicaltrials |
| NCT01955837 | Study of Trifluridine/Tipiracil (TAS-102) in Patients With Metastatic Colorectal Cancer in Asia(TERRA) | completed | Phase 3 | 406 | Taiho Pharmaceutical Co., Ltd.INDUSTRY | 3 | Nov 17, 2020 | clinicaltrials |
| NCT00265811 | Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery | completed | Phase 3 | 2,559 | Federation Francophone de Cancerologie DigestiveOTHER | 1 | Nov 9, 2020 | clinicaltrials |
| NCT01164722 | Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia | completed | Phase 3 | 120 | AIDS Malignancy ConsortiumNETWORK | 1 | Aug 4, 2020 | clinicaltrials |
| NCT03565354 | Efficacy of Preoperative Intravenous Iron in Anaemic Colorectal Cancer Surgical Patients | completed | Phase 3 | 40 | Prince of Wales Hospital, Shatin, Hong KongOTHER | 1 | Jul 20, 2020 | clinicaltrials |
| NCT00726622 | Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Rectal Cancer | completed | Phase 3 | 486 | Alliance for Clinical Trials in OncologyOTHER | 2 | May 7, 2020 | clinicaltrials |
| NCT00003594 | Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer | completed | Phase 3 | 1,691 | Alliance for Clinical Trials in OncologyOTHER | 4 | Apr 29, 2020 | clinicaltrials |
| NCT04342676 | Lymph Node Ratio and Kras Mutation in R Colon Cancer | completed | Phase 3 | 433 | Mansoura UniversityOTHER | 1 | Apr 13, 2020 | clinicaltrials |
| NCT00002570 | Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease | completed | Phase 3 | 67 | NCIC Clinical Trials GroupNETWORK | 1 | Apr 6, 2020 | clinicaltrials |
| NCT00952029 | Combination Chemotherapy and Bevacizumab With or Without Bevacizumab Maintenance Therapy in Treating Patients With Metastatic Colorectal Cancer | completed | Phase 2 / Phase 3 | 492 | Federation Francophone de Cancerologie DigestiveOTHER | 1 | Mar 30, 2020 | clinicaltrials |
| NCT00272324 | Aspirin/Folate Prevention of Large Bowel Polyps | completed | Phase 2 / Phase 3 | 1,121 | Dartmouth-Hitchcock Medical CenterOTHER | 2 | Mar 13, 2020 | clinicaltrials |
| NCT00069121 | A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer | completed | Phase 3 | 1,886 | Hoffmann-La RocheINDUSTRY | 29 | Mar 6, 2020 | clinicaltrials |
| NCT02314819 | A Phase III Trial Evaluating Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients （FRESCO)(FRESCO) | completed | Phase 3 | 416 | Hutchison Medipharma LimitedINDUSTRY | 1 | Feb 17, 2020 | clinicaltrials |
| NCT01228734 | A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC) in Chinese Rat Sarcoma Viral Oncogene Homolog (RAS) Wild-type Patients(TAILOR) | completed | Phase 3 | 553 | Merck KGaA, Darmstadt, GermanyINDUSTRY | 1 | Jan 28, 2020 | clinicaltrials |
| NCT00706121 | S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000(ACP) | completed | Phase 3 | 8,094 | SWOG Cancer Research NetworkNETWORK | 1 | Dec 16, 2019 | clinicaltrials |
| NCT02788279 | A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370) | completed | Phase 3 | 363 | Hoffmann-La RocheINDUSTRY | 11 | Dec 11, 2019 | clinicaltrials |
| NCT02251977 | Effect of GM1 in Prevention of Oxaliplatin Induced Neurotoxicity in Stage II/III Colorectal Cancer | completed | Phase 3 | 196 | Yuhong LiOTHER | 1 | Oct 7, 2019 | clinicaltrials |
Data updated 22 days agoSource updated Nov 1, 2023source: clinicaltrials