Cancer Family
Malignant Head and Neck Neoplasm
CI-CAN-00000236Explore in graph →
1,432 active trials17 approved drugs142 evidence items
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Cancer Family
CI-CAN-00000236Explore in graph →
Clinical trials
5,449 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (629)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06725368 | Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck(CARPACCIO) | recruiting | Phase 2 | 46 | Centre Paul StraussOTHER | 1 | Dec 23, 2025 | clinicaltrials |
| NCT07248956 | Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma | recruiting | Phase 2 | 116 | Eye & ENT Hospital of Fudan UniversityOTHER | 1 |
| Dec 23, 2025 |
| clinicaltrials |
| NCT06659146 | Thermotherapy in Addition to SOC Palliative Radiotherapy(ThermoRad wIRA) | recruiting | N/A | 60 | King's College LondonOTHER | 1 | Dec 22, 2025 | clinicaltrials |
| NCT07296250 | Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT | recruiting | N/A | 100 | Chang Gung Memorial HospitalOTHER | 1 | Dec 22, 2025 | clinicaltrials |
| NCT07227792 | Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Head and Neck Cancer | recruiting | N/A | 35 | Yvonne MoweryOTHER | 1 | Dec 17, 2025 | clinicaltrials |
| NCT07237672 | AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients | recruiting | N/A | 65 | National Taiwan University HospitalOTHER | 1 | Dec 16, 2025 | clinicaltrials |
| NCT06606028 | Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma | recruiting | — | 250 | University of California, San FranciscoOTHER | 1 | Dec 12, 2025 | clinicaltrials |
| NCT03556228 | VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma | recruiting | Phase 1 / Phase 2 | 242 | VM Oncology, LLCINDUSTRY | 2 | Dec 11, 2025 | clinicaltrials |
| NCT05793151 | Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy(ENDURE) | recruiting | N/A | 532 | Medical University of South CarolinaOTHER | 1 | Dec 11, 2025 | clinicaltrials |
| NCT06943521 | A Study of MT-4561 in Patients With Various Advanced Solid Tumors | recruiting | Phase 1 / Phase 2 | 27 | Tanabe Pharma America, Inc.INDUSTRY | 2 | Dec 11, 2025 | clinicaltrials |
| NCT07277764 | Induction High-Low Dose Radiotherapy Plus Anti-PD-1 Followed by Definitive Radiotherapy in Recurrent Nasopharyngeal Carcinoma (Single-Arm Phase II)(REDEFINE) | recruiting | Phase 2 | 23 | Jiangxi Provincial Cancer HospitalOTHER | 1 | Dec 11, 2025 | clinicaltrials |
| NCT07188584 | Phase III Non-Inferiority Trial: Reduced-Target vs. Full-Target IMRT After Chemo in Immunotherapy-Treated Metastatic Nasopharyngeal Cancer | recruiting | Phase 3 | 166 | Ming-Yuan ChenOTHER | 1 | Dec 9, 2025 | clinicaltrials |
| NCT06593639 | Effect of Prehabilitation on Head and Neck Cancer Patients(HNCANCERFIT) | recruiting | N/A | 60 | Laura Deborah LocatiOTHER | 1 | Dec 5, 2025 | clinicaltrials |
| NCT04908696 | Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC) | recruiting | — | 1,000 | Eye & ENT Hospital of Fudan UniversityOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT06623578 | Comparative Study of Transaxillary Robotic Thyroidectomy With MRND Versus Conventional Open Surgery in N1b PTC | recruiting | N/A | 876 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Dec 3, 2025 | clinicaltrials |
| NCT07258979 | A Study of YL201 in Combination With Toripalimab and With or Without Cisplatin in Nasopharyngeal Carcinoma. | recruiting | Phase 1 / Phase 2 | 202 | MediLink Therapeutics (Suzhou) Co., Ltd.INDUSTRY | 1 | Dec 2, 2025 | clinicaltrials |
| NCT07253402 | Microbiota-guided Radiotherapy for Head and Neck Cancer(MIGRAHN) | recruiting | — | 100 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 1 | Nov 28, 2025 | clinicaltrials |
| NCT04842162 | Study Evaluating Near-infrared Imaging Coupled With Indocyanine Green for Intraoperative Control of Resection Margins in ENT Surgery(MAGNOLIA) | recruiting | Phase 2 | 65 | Gustave Roussy, Cancer Campus, Grand ParisOTHER | 2 | Nov 26, 2025 | clinicaltrials |
| NCT06080503 | Phase II Randomized Study of Hypofractionated Versus Conventional Radiotherapy(G-FORCE) | recruiting | N/A | 67 | University of Texas Southwestern Medical CenterOTHER | 1 | Nov 26, 2025 | clinicaltrials |
| NCT06107686 | A Study of YL202 in Selected Patients With Advanced Solid Tumors | recruiting | Phase 2 | 200 | MediLink Therapeutics (Suzhou) Co., Ltd.INDUSTRY | 1 | Nov 26, 2025 | clinicaltrials |
| NCT07154069 | Adaptive Immunotherapy for Nasopharyngeal Carcinoma | recruiting | Phase 3 | 802 | Sun Yat-sen UniversityOTHER | 1 | Nov 25, 2025 | clinicaltrials |
| NCT05333523 | Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study.(PRIMO) | recruiting | Phase 3 | 242 | Radboud University Medical CenterOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT05768178 | DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.(DETERMINE) | recruiting | Phase 2 / Phase 3 | 30 | Cancer Research UKOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT06332755 | Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC(LB-LR1109) | recruiting | Phase 1 | 76 | LG ChemINDUSTRY | 1 | Nov 24, 2025 | clinicaltrials |
| NCT06839066 | A Phase II Study to Evaluate HLX43 in Subjects With Recurrent/Metastatic Nasopharyngeal Carcinoma Failed or Intolerance to Second-line Therapy | recruiting | Phase 2 | 70 | Shanghai Henlius BiotechINDUSTRY | 1 | Nov 24, 2025 | clinicaltrials |
| NCT07081984 | Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid Tumors | recruiting | Phase 1 | 12 | TherornaINDUSTRY | 1 | Nov 24, 2025 | clinicaltrials |
| NCT07106827 | A Study of GV20-0251 in Advanced or Refractory Solid Tumors | recruiting | Phase 1 | 10 | West China HospitalOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT07232680 | Prospective Immuno-Radiomic Profiling in Nasopharyngeal Carcinoma Treated With Proton or Photon Chemoradiotherapy(IMPRINT) | recruiting | — | 500 | Cheng-En HsiehOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT07095608 | Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain | recruiting | N/A | 80 | New York UniversityOTHER | 1 | Nov 21, 2025 | clinicaltrials |
| NCT07235566 | MRG003 and Pucotenlimab to Treat Locally Advanced or Metastatic ATC/PDTC | recruiting | Phase 2 | 60 | Fudan UniversityOTHER | 1 | Nov 19, 2025 | clinicaltrials |
| NCT06127784 | Survivorship After HNC: A Randomized Controlled Trial Evaluating Patient Care and Adherence to Follow-up | recruiting | N/A | 176 | Western University, CanadaOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT05024929 | Targeted Therapy to Increase RAI Uptake in Metastatic DTC | recruiting | — | 32 | Children's Hospital of PhiladelphiaOTHER | 2 | Nov 14, 2025 | clinicaltrials |
| NCT05783323 | Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer | recruiting | Phase 2 | 13 | Children's Hospital of PhiladelphiaOTHER | 1 | Nov 14, 2025 | clinicaltrials |
| NCT06088381 | Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)(SAVAL) | recruiting | Phase 2 | 61 | University of Maryland, BaltimoreOTHER | 1 | Nov 10, 2025 | clinicaltrials |
| NCT06985784 | Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers | recruiting | N/A | 40 | City of Hope Medical CenterOTHER | 1 | Nov 10, 2025 | clinicaltrials |
| NCT05902988 | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | recruiting | Phase 1 / Phase 2 | 200 | Volastra Therapeutics, Inc.INDUSTRY | 1 | Nov 4, 2025 | clinicaltrials |
| NCT00898638 | Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants | recruiting | — | 8,000 | Vanderbilt University Medical CenterOTHER | 1 | Oct 28, 2025 | clinicaltrials |
| NCT03452774 | SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry | recruiting | — | 50,000 | Massive Bio, Inc.INDUSTRY | 2 | Oct 28, 2025 | clinicaltrials |
| NCT05999630 | Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer | recruiting | Phase 3 | 100 | Vanderbilt University Medical CenterOTHER | 1 | Oct 28, 2025 | clinicaltrials |
| NCT06914999 | Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer | recruiting | Early Phase 1 | 20 | Emory UniversityOTHER | 1 | Oct 22, 2025 | clinicaltrials |
| NCT06597565 | A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC | recruiting | Phase 2 | 43 | H. Lee Moffitt Cancer Center and Research InstituteOTHER | 1 | Oct 20, 2025 | clinicaltrials |
| NCT03517579 | Personalized Treatment in Thyroid Disorders | recruiting | N/A | 10 | Johns Hopkins UniversityOTHER | 1 | Oct 15, 2025 | clinicaltrials |
| NCT04632654 | A Motion Exergaming Approach for Symptom Management: HNC | recruiting | N/A | 150 | University of Alabama at BirminghamOTHER | 1 | Oct 15, 2025 | clinicaltrials |
| NCT06699212 | A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases(ECLIPSE) | recruiting | Phase 3 | 412 | Rakuten Medical, Inc.INDUSTRY | 3 | Oct 15, 2025 | clinicaltrials |
| NCT04370587 | A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors | recruiting | Phase 1 / Phase 2 | 30 | ImmVira Pharma Co. LtdINDUSTRY | 2 | Oct 8, 2025 | clinicaltrials |
| NCT07189897 | Apixaban or Enoxaparin After Head and Neck Cancer Surgery | recruiting | Phase 4 | 76 | Kiranya ArnoldOTHER | 1 | Oct 8, 2025 | clinicaltrials |
| NCT04057209 | VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer(VoiceS) | recruiting | N/A | 34 | Olgun ElicinOTHER | 3 | Oct 7, 2025 | clinicaltrials |
| NCT07211139 | Head and Neck Advanced Research for Multi-Omics and Optimized Immunotherapy(HARMONI) | recruiting | — | 30 | Samsung Medical CenterOTHER | 1 | Oct 7, 2025 | clinicaltrials |
| NCT06222606 | Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism | recruiting | N/A | 160 | Aarhus University HospitalOTHER | 1 | Oct 6, 2025 | clinicaltrials |
| NCT05945875 | Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer | recruiting | Phase 1 | 40 | Vanderbilt-Ingram Cancer CenterOTHER | 1 | Oct 3, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Dec 23, 2025source: clinicaltrials