Clinical trial · Observational
Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma
Tumor-informed ctDNA Testing for Minimal Residual Disease Monitoring Following Curative-intent Treatment of Squamous Cell Carcinoma of the Head and Neck.
NCT06606028CI-TRIAL-00098877recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a single-center, non-interventional, observational study that evaluates the correlation of circulating tumor DNA (ctDNA) testing to cancer relapse for participants with squamous cell carcinomas (HNC) of the head and neck mucosa and skin after curative-intent primary radiation or surgery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cutaneous Squamous Cell Carcinoma (CSCC) | Skin Squamous Cell Carcinoma | ALIAS | 0.85 |
| Squamous Cell Carcinoma Head and Neck Cancer (HNSCC) | Head and Neck Squamous Cell Carcinoma | ALIAS | 0.85 |
| Squamous Cell Carcinoma of Head and Neck | Head and Neck Squamous Cell Carcinoma | ALIAS | 0.90 |
| Squamous Cell Carcinoma of Skin | Skin Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Specimen Collection | Procedure | — | UNRESOLVED |
| Medical Record Review | Other | — | UNRESOLVED |
| Tumor Tissue Collection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Cohort A: Non-investigational Radiation therapy
- description
- Participants will have tumor tissue collected at screening and blood samples (approximately 20ml x 3) will be obtained during non-investigational, standard of care radiation and after care for up to 2 years.
- interventionNames
- Procedure: Blood Specimen Collection
- Procedure: Tumor Tissue Collection
- Other: Medical Record Review
- label
- Cohort B: Non-investigational Surgery
- description
- Participants will have tumor tissue collected at screening and blood samples (approximately 20ml x 3) will be obtained during non-investigational, standard of care surgery and after care for up to 2 years.
- interventionNames
- Procedure: Blood Specimen Collection
- Procedure: Tumor Tissue Collection
- Other: Medical Record Review
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Participants must have histologically or cytologically confirmed squamous cell carcinoma of the head and neck mucosa and skin. 2. Participants must be age \>=18 years. 3. Participants must be planning to receive curative-intent surgery or radiation-based treatment as part of standard of care treatment. 4. Participants must have the ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 1\. Contraindication to phlebotomy for removal of 20 mL of peripheral blood each time point (up to 300 mL total over 15 time points).
References
Publications (0)
Data not yet available
No reference posted for this study.