Cancer
Malignant Central Nervous System Neoplasm
CI-CAN-00001115Explore in graph →
Top-level822 active trials5 approved drugs103 evidence items
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Cancer
CI-CAN-00001115Explore in graph →
Genomics
10 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
491 cases with simple somatic mutation data · 491 cases total · 2026-01-16 · mapped to Medulloblastoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PTCH1 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 51 |
| 491 |
| 10.4% |
| cbioportal |
| 2 | TERT | Ssm | 50 | 491 | 10.2% | cbioportal |
| 3 | DDX3X | Ssm | 43 | 491 | 8.8% | cbioportal |
| 4 | KMT2D | Ssm | 34 | 491 | 6.9% | cbioportal |
| 5 | CTNNB1 | Ssm | 32 | 491 | 6.5% | cbioportal |
| 6 | KMT2C | Ssm | 29 | 491 | 5.9% | cbioportal |
| 7 | SMARCA4 | Ssm | 25 | 491 | 5.1% | cbioportal |
| 8 | TTN | Ssm | 23 | 491 | 4.7% | cbioportal |
| 9 | KBTBD4 | Ssm | 19 | 491 | 3.9% | cbioportal |
| 11 | MUC16 | Ssm | 17 | 491 | 3.5% | cbioportal |
| 10 | KDM6A | Ssm | 17 | 491 | 3.5% | cbioportal |
| 12 | TP53 | Ssm | 17 | 491 | 3.5% | cbioportal |
| 13 | CREBBP | Ssm | 15 | 491 | 3.1% | cbioportal |
| 14 | ZMYM3 | Ssm | 14 | 491 | 2.9% | cbioportal |
| 15 | SMO | Ssm | 13 | 491 | 2.6% | cbioportal |
| 16 | TCF4 | Ssm | 12 | 491 | 2.4% | cbioportal |
| 17 | ZIC1 | Ssm | 12 | 491 | 2.4% | cbioportal |
| 19 | NIN | Ssm | 11 | 491 | 2.2% | cbioportal |
| 18 | CDK1 | Ssm | 11 | 491 | 2.2% | cbioportal |
| 20 | NME5 | Ssm | 11 | 491 | 2.2% | cbioportal |
| 24 | RSBN1L | Ssm | 10 | 491 | 2% | cbioportal |
| 23 | LAMA2 | Ssm | 10 | 491 | 2% | cbioportal |
| 21 | FBXW7 | Ssm | 10 | 491 | 2% | cbioportal |
| 22 | GSE1 | Ssm | 10 | 491 | 2% | cbioportal |
| 25 | CTDNEP1 | Ssm | 9 | 491 | 1.8% | cbioportal |
| 26 | PIK3CA | Ssm | 9 | 491 | 1.8% | cbioportal |
| 28 | MUC17 | Ssm | 8 | 491 | 1.6% | cbioportal |
| 27 | BCOR | Ssm | 8 | 491 | 1.6% | cbioportal |
| 29 | RYR3 | Ssm | 8 | 491 | 1.6% | cbioportal |
| 37 | SUFU | Ssm | 7 | 491 | 1.4% | cbioportal |
Data updated 22 days agoSource updated 2026-01-16